Abstract
Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed. The addition of the long chains to either chrysene or pyrene caused a red-shift in the spectral emission when compared to the corresponding polycyclic aromatic hydrocarbons itself. Furthermore, the cytotoxicity of the three novel polyaromatic compounds was evaluated in vitro in a panel of cultured mammalian cell lines. The pyrenyl ether demonstrated better cytotoxicity compared to cisplatin against colon (HT-29) as well as cervical (HeLa) cancer cell lines. In conclusion, three new compounds were synthesized and investigated in this study. This novel method is likely to play a role in other areas of research.
Original language | English (US) |
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Pages (from-to) | 45-49 |
Number of pages | 5 |
Journal | Oncology Letters |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2012 |
Keywords
- Antitumor
- Cytotoxicity
- Emission spectrum
- Liver cancer
- Polyaromatic
ASJC Scopus subject areas
- Oncology
- Cancer Research