Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity

Debasish Bandyopadhyay, Jose C. Granados, John D. Short, Bimal K. Banik

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed. The addition of the long chains to either chrysene or pyrene caused a red-shift in the spectral emission when compared to the corresponding polycyclic aromatic hydrocarbons itself. Furthermore, the cytotoxicity of the three novel polyaromatic compounds was evaluated in vitro in a panel of cultured mammalian cell lines. The pyrenyl ether demonstrated better cytotoxicity compared to cisplatin against colon (HT-29) as well as cervical (HeLa) cancer cell lines. In conclusion, three new compounds were synthesized and investigated in this study. This novel method is likely to play a role in other areas of research.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalOncology Letters
Volume3
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Antitumor
  • Cytotoxicity
  • Emission spectrum
  • Liver cancer
  • Polyaromatic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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