Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity

Debasish Bandyopadhyay, Jose C. Granados, John D. Short, Bimal K. Banik

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed. The addition of the long chains to either chrysene or pyrene caused a red-shift in the spectral emission when compared to the corresponding polycyclic aromatic hydrocarbons itself. Furthermore, the cytotoxicity of the three novel polyaromatic compounds was evaluated in vitro in a panel of cultured mammalian cell lines. The pyrenyl ether demonstrated better cytotoxicity compared to cisplatin against colon (HT-29) as well as cervical (HeLa) cancer cell lines. In conclusion, three new compounds were synthesized and investigated in this study. This novel method is likely to play a role in other areas of research.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalOncology Letters
Volume3
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Antitumor
  • Cytotoxicity
  • Emission spectrum
  • Liver cancer
  • Polyaromatic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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