Polyarteritis nodosa in a cynomolgus macaque (Macaca fascicularis)

B. F. Porter, P. Frost, G. B. Hubbard

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Polyarteritis nodosa (PAN) is an idiopathic necrotizing vasculitis affecting small- to medium-sized arteries. The disease is well recognized in humans, and PAN-like syndromes have been described in a number of other species. This report describes a case of PAN in a 6-year-old male cynomolgus macaque. The animal had necrotizing arteritis affecting vessels in the kidney, small intestine, colon, heart, spleen, mesentery, urinary bladder, and pancreas. The lesions were segmental in distribution and of varying severity and stage of development. A transmural mixed inflammatory cell infiltrate was present, often accompanied by fibrinoid necrosis of the tunica media and loss of the internal elastic lamina. Immunohistochemical staining showed that many of the infiltrating cells were T lymphocytes and histiocytes, suggesting a cell-mediated component to the pathogenesis.

Original languageEnglish (US)
Pages (from-to)570-573
Number of pages4
JournalVeterinary pathology
Volume40
Issue number5
DOIs
StatePublished - Sep 2003

Keywords

  • Arteries
  • Cardiovascular system
  • Immunohistochemistry
  • Macaca fascicularis
  • Polyarteritis nodosa

ASJC Scopus subject areas

  • veterinary(all)

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