PohnB6F1

A cross of wild and domestic mice that is a new model of extended female reproductive life span

Kevin Flurkey, Yaniv Brandvain, Simon Klebanov, Steven N. Austad, Richard A. Miller, Rong Yuan, David E. Harrison

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans - mean age at last litter of 647 ± 32 days - longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.

Original languageEnglish (US)
Pages (from-to)1187-1198
Number of pages12
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume62
Issue number11
StatePublished - Nov 2007

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Litter Size
Inbred C57BL Mouse
Reproduction
Young Adult
Alleles
Phenotype
Life History Traits

ASJC Scopus subject areas

  • Aging

Cite this

Flurkey, K., Brandvain, Y., Klebanov, S., Austad, S. N., Miller, R. A., Yuan, R., & Harrison, D. E. (2007). PohnB6F1: A cross of wild and domestic mice that is a new model of extended female reproductive life span. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 62(11), 1187-1198.

PohnB6F1 : A cross of wild and domestic mice that is a new model of extended female reproductive life span. / Flurkey, Kevin; Brandvain, Yaniv; Klebanov, Simon; Austad, Steven N.; Miller, Richard A.; Yuan, Rong; Harrison, David E.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 11, 11.2007, p. 1187-1198.

Research output: Contribution to journalArticle

Flurkey, K, Brandvain, Y, Klebanov, S, Austad, SN, Miller, RA, Yuan, R & Harrison, DE 2007, 'PohnB6F1: A cross of wild and domestic mice that is a new model of extended female reproductive life span', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 62, no. 11, pp. 1187-1198.
Flurkey, Kevin ; Brandvain, Yaniv ; Klebanov, Simon ; Austad, Steven N. ; Miller, Richard A. ; Yuan, Rong ; Harrison, David E. / PohnB6F1 : A cross of wild and domestic mice that is a new model of extended female reproductive life span. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2007 ; Vol. 62, No. 11. pp. 1187-1198.
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