Abstract
In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans - mean age at last litter of 647 ± 32 days - longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1187-1198 |
| Number of pages | 12 |
| Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
| Volume | 62 |
| Issue number | 11 |
| State | Published - Nov 2007 |
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ASJC Scopus subject areas
- Aging
Cite this
PohnB6F1 : A cross of wild and domestic mice that is a new model of extended female reproductive life span. / Flurkey, Kevin; Brandvain, Yaniv; Klebanov, Simon; Austad, Steven N.; Miller, Richard A.; Yuan, Rong; Harrison, David E.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 11, 11.2007, p. 1187-1198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PohnB6F1
T2 - A cross of wild and domestic mice that is a new model of extended female reproductive life span
AU - Flurkey, Kevin
AU - Brandvain, Yaniv
AU - Klebanov, Simon
AU - Austad, Steven N.
AU - Miller, Richard A.
AU - Yuan, Rong
AU - Harrison, David E.
PY - 2007/11
Y1 - 2007/11
N2 - In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans - mean age at last litter of 647 ± 32 days - longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.
AB - In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans - mean age at last litter of 647 ± 32 days - longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.
UR - http://www.scopus.com/inward/record.url?scp=37349104182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37349104182&partnerID=8YFLogxK
M3 - Article
C2 - 18000137
AN - SCOPUS:37349104182
VL - 62
SP - 1187
EP - 1198
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 11
ER -