PohnB6F1: A cross of wild and domestic mice that is a new model of extended female reproductive life span

Kevin Flurkey; Yaniv Brandvain; Simon Klebanov; Steven N. Austad; Richard A. Miller; Rong Yuan; David E. Harrison

doi:10.1093/gerona/62.11.1187

PohnB6F1: A cross of wild and domestic mice that is a new model of extended female reproductive life span

Kevin Flurkey, Yaniv Brandvain, Simon Klebanov, Steven N. Austad, Richard A. Miller, Rong Yuan, David E. Harrison

Barshop Institute

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans - mean age at last litter of 647 ± 32 days - longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.

Original language	English (US)
Pages (from-to)	1187-1198
Number of pages	12
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	62
Issue number	11
DOIs	https://doi.org/10.1093/gerona/62.11.1187
State	Published - Nov 2007

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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PohnB6F1 : A cross of wild and domestic mice that is a new model of extended female reproductive life span. / Flurkey, Kevin; Brandvain, Yaniv; Klebanov, Simon; Austad, Steven N.; Miller, Richard A.; Yuan, Rong; Harrison, David E.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 11, 11.2007, p. 1187-1198.

Research output: Contribution to journal › Article › peer-review

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abstract = "In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans - mean age at last litter of 647 ± 32 days - longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.",

author = "Kevin Flurkey and Yaniv Brandvain and Simon Klebanov and Austad, {Steven N.} and Miller, {Richard A.} and Rong Yuan and Harrison, {David E.}",

note = "Funding Information: ACKNOWLEDGMENTS This work was supported by grants RR-14455, AG-025007, and AG025707 (DEH); Maine Biomed Res Infrastructure/NCRR/2 P20 RR016463 and The Goldwater Fellowship Foundation (YB); and The Jackson Laboratory cancer core grant HL63230.",

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