Pneumonia due to chlamydia trachomatis in the immunocompromised (Nude) mouse

Dwight M. Williams; Julius Schachterv; David J. Drutz; Ciro V. Sumaya

doi:10.1093/infdis/143.2.238

Pneumonia due to chlamydia trachomatis in the immunocompromised (Nude) mouse

Dwight M. Williams, Julius Schachterv, David J. Drutz, Ciro V. Sumaya

Department of Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Athymic nude mice (nu/nu) were significantly more susceptible to pneumonia due to the agent of mouse pneumonitis (MoPn), Chlamydia trachomatis, than their heterozygous (nu/+) littermates, as judged both by a greater mortality and a decreased ability to rid their lungs of the infection, Nu/nu mice did not produce significant antibody to the MoPn agent, whereas nu/+ mice did. Thymic transplantation rendered nu/nu mice significantly more resistant to the MoPn agent than nu/nu controls. Resistance to the MoPn agent and production of specific antibody to the MoPn agent were dependent on thymus-derived cells.

Original language	English (US)
Pages (from-to)	238-241
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	143
Issue number	2
DOIs	https://doi.org/10.1093/infdis/143.2.238
State	Published - Feb 1981

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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title = "Pneumonia due to chlamydia trachomatis in the immunocompromised (Nude) mouse",

abstract = "Athymic nude mice (nu/nu) were significantly more susceptible to pneumonia due to the agent of mouse pneumonitis (MoPn), Chlamydia trachomatis, than their heterozygous (nu/+) littermates, as judged both by a greater mortality and a decreased ability to rid their lungs of the infection, Nu/nu mice did not produce significant antibody to the MoPn agent, whereas nu/+ mice did. Thymic transplantation rendered nu/nu mice significantly more resistant to the MoPn agent than nu/nu controls. Resistance to the MoPn agent and production of specific antibody to the MoPn agent were dependent on thymus-derived cells.",

author = "Williams, {Dwight M.} and Julius Schachterv and Drutz, {David J.} and Sumaya, {Ciro V.}",

note = "Funding Information: This work was supported in part by funds from the General Medical Research Service of the Veterans Administration and by grants no. HD-12271, no. EY-01205,and no. EY-02216from the National Institutes of Health.",

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doi = "10.1093/infdis/143.2.238",

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AU - Williams, Dwight M.

AU - Schachterv, Julius

AU - Drutz, David J.

AU - Sumaya, Ciro V.

N1 - Funding Information: This work was supported in part by funds from the General Medical Research Service of the Veterans Administration and by grants no. HD-12271, no. EY-01205,and no. EY-02216from the National Institutes of Health.

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N2 - Athymic nude mice (nu/nu) were significantly more susceptible to pneumonia due to the agent of mouse pneumonitis (MoPn), Chlamydia trachomatis, than their heterozygous (nu/+) littermates, as judged both by a greater mortality and a decreased ability to rid their lungs of the infection, Nu/nu mice did not produce significant antibody to the MoPn agent, whereas nu/+ mice did. Thymic transplantation rendered nu/nu mice significantly more resistant to the MoPn agent than nu/nu controls. Resistance to the MoPn agent and production of specific antibody to the MoPn agent were dependent on thymus-derived cells.

AB - Athymic nude mice (nu/nu) were significantly more susceptible to pneumonia due to the agent of mouse pneumonitis (MoPn), Chlamydia trachomatis, than their heterozygous (nu/+) littermates, as judged both by a greater mortality and a decreased ability to rid their lungs of the infection, Nu/nu mice did not produce significant antibody to the MoPn agent, whereas nu/+ mice did. Thymic transplantation rendered nu/nu mice significantly more resistant to the MoPn agent than nu/nu controls. Resistance to the MoPn agent and production of specific antibody to the MoPn agent were dependent on thymus-derived cells.

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Pneumonia due to chlamydia trachomatis in the immunocompromised (Nude) mouse

Abstract

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