Pneumonia due to chlamydia trachomatis in the immunocompromised (Nude) mouse

Dwight M. Williams, Julius Schachterv, David J. Drutz, Ciro V. Sumaya

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Athymic nude mice (nu/nu) were significantly more susceptible to pneumonia due to the agent of mouse pneumonitis (MoPn), Chlamydia trachomatis, than their heterozygous (nu/+) littermates, as judged both by a greater mortality and a decreased ability to rid their lungs of the infection, Nu/nu mice did not produce significant antibody to the MoPn agent, whereas nu/+ mice did. Thymic transplantation rendered nu/nu mice significantly more resistant to the MoPn agent than nu/nu controls. Resistance to the MoPn agent and production of specific antibody to the MoPn agent were dependent on thymus-derived cells.

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalJournal of Infectious Diseases
Volume143
Issue number2
DOIs
StatePublished - Feb 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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