Pneumonia as a cardiovascular disease

Marcos I. Restrepo, Luis F. Reyes

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Community-acquired pneumonia (CAP) is an important cause of death around the globe. Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (i.e. new/worsening heart failure, new/worsening arrhythmias, myocardial infarctions and/or strokes), acutely and up to 10 years thereafter. Cardiac complications result from complex interactions between preexisting conditions, relative ischaemia, upregulation of the sympathetic system, systemic inflammation and direct pathogen-mediated damage to the cardiovascular system. The exact mechanisms underlying the direct host–pathogen interactions are of great interest to identify potential therapeutic and preventative targets for CAP. In this review, we summarize the epidemiological data, risk factors and the pathogen-driven cardiovascular damage affecting patients with CAP.

Original languageEnglish (US)
Pages (from-to)250-259
Number of pages10
Issue number3
StatePublished - Mar 2018


  • arrhythmias
  • heart failure
  • myocardial infarction
  • pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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