TY - JOUR
T1 - Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix
AU - Paterson, Gavin K.
AU - Orihuela, Carlos J.
PY - 2010/7
Y1 - 2010/7
N2 - The attachment of bacteria to host cells and tissues, and their subsequent invasion and dissemination are key processes during pathogenesis. In this issue of Molecular Microbiology, Jensch and co-workers provide further molecular insight into these events during infection with the Gram positive bacterium Streptococcus pneumoniae. Their characterization of pneumococcal adherence and virulence factor B (PavB), a bacterial surface protein with orthologues in other streptococci, show that it binds to the extracellar matrix components fibronection and plasminogen by virtue of repetitive sequences-designated streptococcal surface repeats. In mice, a pavB mutant showed reduced nasopharyngeal colonization and was attenuated in a lung infection model. As discussed here in the context of the pneumococcus, the study of PavB highlights the central role during microbal pathogenesis of targetting the extracellular matrix by so-called microbial surface components recognizing adhesive matrix molecules (MSCRAMMs).
AB - The attachment of bacteria to host cells and tissues, and their subsequent invasion and dissemination are key processes during pathogenesis. In this issue of Molecular Microbiology, Jensch and co-workers provide further molecular insight into these events during infection with the Gram positive bacterium Streptococcus pneumoniae. Their characterization of pneumococcal adherence and virulence factor B (PavB), a bacterial surface protein with orthologues in other streptococci, show that it binds to the extracellar matrix components fibronection and plasminogen by virtue of repetitive sequences-designated streptococcal surface repeats. In mice, a pavB mutant showed reduced nasopharyngeal colonization and was attenuated in a lung infection model. As discussed here in the context of the pneumococcus, the study of PavB highlights the central role during microbal pathogenesis of targetting the extracellular matrix by so-called microbial surface components recognizing adhesive matrix molecules (MSCRAMMs).
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U2 - 10.1111/j.1365-2958.2010.07190.x
DO - 10.1111/j.1365-2958.2010.07190.x
M3 - Comment/debate
C2 - 20444102
AN - SCOPUS:77953977960
VL - 77
SP - 1
EP - 5
JO - Molecular Microbiology
JF - Molecular Microbiology
SN - 0950-382X
IS - 1
ER -