Pnc1p supports increases in cellular NAD(H) levels in response to internal or external oxidative stress

Karyl I. Minard, Lee McAlister-Henn

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Following transfer from medium with fermentable glucose to medium with nonfermentable acetate as the carbon source, cellular levels of NAD(H) were found to increase ∼2-fold in a parental yeast strain. Similar transfer of a mutant strain subject to endogenous oxidative stress under these conditions produced more dramatic increases in cellular levels of NAD(H), and elevations above parental levels were shown to be due to the nicotinimidase Pnc1p. Similar transient increases in NAD(H) levels observed in the parental strain following addition of exogenous hydrogen peroxide were also attributable to Pnc1p.

Original languageEnglish (US)
Pages (from-to)6299-6301
Number of pages3
JournalBiochemistry
Volume49
Issue number30
DOIs
StatePublished - Aug 3 2010

ASJC Scopus subject areas

  • Biochemistry

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