Pnc1p supports increases in cellular NAD(H) levels in response to internal or external oxidative stress

Karyl I. Minard; Lee McAlister-Henn

doi:10.1021/bi100825z

Pnc1p supports increases in cellular NAD(H) levels in response to internal or external oxidative stress

Karyl I. Minard, Lee McAlister-Henn

Biochemistry & Structural Biology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Following transfer from medium with fermentable glucose to medium with nonfermentable acetate as the carbon source, cellular levels of NAD(H) were found to increase ∼2-fold in a parental yeast strain. Similar transfer of a mutant strain subject to endogenous oxidative stress under these conditions produced more dramatic increases in cellular levels of NAD(H), and elevations above parental levels were shown to be due to the nicotinimidase Pnc1p. Similar transient increases in NAD(H) levels observed in the parental strain following addition of exogenous hydrogen peroxide were also attributable to Pnc1p.

Original language	English (US)
Pages (from-to)	6299-6301
Number of pages	3
Journal	Biochemistry
Volume	49
Issue number	30
DOIs	https://doi.org/10.1021/bi100825z
State	Published - Aug 3 2010

ASJC Scopus subject areas

Biochemistry

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title = "Pnc1p supports increases in cellular NAD(H) levels in response to internal or external oxidative stress",

abstract = "Following transfer from medium with fermentable glucose to medium with nonfermentable acetate as the carbon source, cellular levels of NAD(H) were found to increase ∼2-fold in a parental yeast strain. Similar transfer of a mutant strain subject to endogenous oxidative stress under these conditions produced more dramatic increases in cellular levels of NAD(H), and elevations above parental levels were shown to be due to the nicotinimidase Pnc1p. Similar transient increases in NAD(H) levels observed in the parental strain following addition of exogenous hydrogen peroxide were also attributable to Pnc1p.",

author = "Minard, {Karyl I.} and Lee McAlister-Henn",

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AU - Minard, Karyl I.

AU - McAlister-Henn, Lee

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N2 - Following transfer from medium with fermentable glucose to medium with nonfermentable acetate as the carbon source, cellular levels of NAD(H) were found to increase ∼2-fold in a parental yeast strain. Similar transfer of a mutant strain subject to endogenous oxidative stress under these conditions produced more dramatic increases in cellular levels of NAD(H), and elevations above parental levels were shown to be due to the nicotinimidase Pnc1p. Similar transient increases in NAD(H) levels observed in the parental strain following addition of exogenous hydrogen peroxide were also attributable to Pnc1p.

AB - Following transfer from medium with fermentable glucose to medium with nonfermentable acetate as the carbon source, cellular levels of NAD(H) were found to increase ∼2-fold in a parental yeast strain. Similar transfer of a mutant strain subject to endogenous oxidative stress under these conditions produced more dramatic increases in cellular levels of NAD(H), and elevations above parental levels were shown to be due to the nicotinimidase Pnc1p. Similar transient increases in NAD(H) levels observed in the parental strain following addition of exogenous hydrogen peroxide were also attributable to Pnc1p.

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JF - Biochemistry

SN - 0006-2960

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ER -

Pnc1p supports increases in cellular NAD(H) levels in response to internal or external oxidative stress

Abstract

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