Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage

Emma E M Knowles, Reese McKay, Jack W. Kent, Emma Sprooten, Melanie A. Carless, Joanne E. Curran, Marcio A A De Almeida, Thomas D. Dyer, Harald H H Göring, Rene L Olvera, Ravi Duggirala, Peter T Fox, Laura Almasy, John Blangero, David C. Glahn

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The role of the amygdala in emotion recognition is well established, and amygdala volume and emotion recognition performance have each been shown separately to be highly heritable traits, but the potential role of common genetic influences on both traits has not been explored. The authors investigated the pleiotropic influences of amygdala volume and emotion recognition performance. Method: In a sample of randomly selected extended pedigrees (N=858), the authors used a combination of univariate and bivariate linkage to investigate pleiotropy between amygdala volume and emotion recognition performance and followed up with association analysis. Results: The authors found a pleiotropic region for amygdala volume and emotion recognition performance on chromosome 4q26 (LOD score=4.40). Association analysis conducted in the region underlying the bivariate linkage peak revealed a variant meeting the corrected significance level (Bonferroni-corrected p=5.01×10-5) within an intron of PDE5A (rs2622497, p=4.4×10-5) as being jointly influential on both traits. PDE5A has been implicated previously in recognition-memory deficits and is expressed in subcortical structures that are thought to underlie memory ability, including the amygdala. Conclusions: This study extends our understanding of the shared etiology between the amygdala and emotion recognition by showing that the overlap between amygdala volume and emotion recognition performance is due at least in part to common genetic influences. Moreover, this study identifies a pleiotropic locus for the two traits and an associated variant, which localizes the genetic signal even more precisely. These results, when taken in the context of previous research, highlight the potential utility of PDE5 inhibitors for ameliorating emotion recognition deficits in individuals suffering from mental or neurodegenerative illness.

Original languageEnglish (US)
Pages (from-to)190-199
Number of pages10
JournalAmerican Journal of Psychiatry
Volume172
Issue number2
DOIs
StatePublished - Feb 1 2015

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Amygdala
Emotions
Recognition (Psychology)
Emotion Recognition
Locus
Linkage
Phosphodiesterase 5 Inhibitors
Aptitude
Memory Disorders
Pedigree
Psychological Stress
Introns
Chromosomes
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Arts and Humanities (miscellaneous)

Cite this

Knowles, E. E. M., McKay, R., Kent, J. W., Sprooten, E., Carless, M. A., Curran, J. E., ... Glahn, D. C. (2015). Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage. American Journal of Psychiatry, 172(2), 190-199. https://doi.org/10.1176/appi.ajp.2014.14030311

Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage. / Knowles, Emma E M; McKay, Reese; Kent, Jack W.; Sprooten, Emma; Carless, Melanie A.; Curran, Joanne E.; De Almeida, Marcio A A; Dyer, Thomas D.; Göring, Harald H H; Olvera, Rene L; Duggirala, Ravi; Fox, Peter T; Almasy, Laura; Blangero, John; Glahn, David C.

In: American Journal of Psychiatry, Vol. 172, No. 2, 01.02.2015, p. 190-199.

Research output: Contribution to journalArticle

Knowles, EEM, McKay, R, Kent, JW, Sprooten, E, Carless, MA, Curran, JE, De Almeida, MAA, Dyer, TD, Göring, HHH, Olvera, RL, Duggirala, R, Fox, PT, Almasy, L, Blangero, J & Glahn, DC 2015, 'Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage', American Journal of Psychiatry, vol. 172, no. 2, pp. 190-199. https://doi.org/10.1176/appi.ajp.2014.14030311
Knowles, Emma E M ; McKay, Reese ; Kent, Jack W. ; Sprooten, Emma ; Carless, Melanie A. ; Curran, Joanne E. ; De Almeida, Marcio A A ; Dyer, Thomas D. ; Göring, Harald H H ; Olvera, Rene L ; Duggirala, Ravi ; Fox, Peter T ; Almasy, Laura ; Blangero, John ; Glahn, David C. / Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage. In: American Journal of Psychiatry. 2015 ; Vol. 172, No. 2. pp. 190-199.
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abstract = "Objective: The role of the amygdala in emotion recognition is well established, and amygdala volume and emotion recognition performance have each been shown separately to be highly heritable traits, but the potential role of common genetic influences on both traits has not been explored. The authors investigated the pleiotropic influences of amygdala volume and emotion recognition performance. Method: In a sample of randomly selected extended pedigrees (N=858), the authors used a combination of univariate and bivariate linkage to investigate pleiotropy between amygdala volume and emotion recognition performance and followed up with association analysis. Results: The authors found a pleiotropic region for amygdala volume and emotion recognition performance on chromosome 4q26 (LOD score=4.40). Association analysis conducted in the region underlying the bivariate linkage peak revealed a variant meeting the corrected significance level (Bonferroni-corrected p=5.01×10-5) within an intron of PDE5A (rs2622497, p=4.4×10-5) as being jointly influential on both traits. PDE5A has been implicated previously in recognition-memory deficits and is expressed in subcortical structures that are thought to underlie memory ability, including the amygdala. Conclusions: This study extends our understanding of the shared etiology between the amygdala and emotion recognition by showing that the overlap between amygdala volume and emotion recognition performance is due at least in part to common genetic influences. Moreover, this study identifies a pleiotropic locus for the two traits and an associated variant, which localizes the genetic signal even more precisely. These results, when taken in the context of previous research, highlight the potential utility of PDE5 inhibitors for ameliorating emotion recognition deficits in individuals suffering from mental or neurodegenerative illness.",
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AU - Carless, Melanie A.

AU - Curran, Joanne E.

AU - De Almeida, Marcio A A

AU - Dyer, Thomas D.

AU - Göring, Harald H H

AU - Olvera, Rene L

AU - Duggirala, Ravi

AU - Fox, Peter T

AU - Almasy, Laura

AU - Blangero, John

AU - Glahn, David C.

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