Pleiotropic genetic influences on event-related brain potentials and alcoholism

L. Almasy, J. T. Williams, B. Porjesz, T. Reich, J. Blangero, H. Begleiter

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Several groups have demonstrated reduced P3(00) amplitudes of the event-related brain potential in abstinent alcoholics and their offspring, making P3 a promising quantitative marker for liability to alcoholism. To assess whether correlations between P3 amplitude and alcoholism stem from shared genetic influences, we performed bivariate genetic analyses on these traits. Visual P3s were recorded from 19 electrodes for 607 individuals in 103 families ascertained through an alcoholic proband with two first degree relatives who also met COGA alcohol dependence criteria (DSM-III-R and Feighner definite). Subjects were genotyped for approximately 275 polymorphic markers spaced at approximately 15 cM intervals. Bivariate quantitative genetic and linkage analyses were performed with SOLAR. DSM-IV, ICD-10, and COGA diagnoses were analyzed with similar results. Genetic correlations were strongest with the COGA diagnosis. P3 amplitude at all leads showed negative genetic correlations with alcoholism, indicating the presence of pleiotropic loci which reduce P3 and increase liability to disease. Environmental correlations were not significantly different from zero. Genetic correlations were strongest at central and temporal leads (-0.61 to -0.70, P < 0.01) and weakest at the occipital leads (-0.04, P > 0.10). We performed bivariate linkage screens of the three diagnoses with P3 amplitude at Cz. The pattern of results was similar across diagnoses, but the strongest evidence for linkage was obtained with DSM-IV. A chromosome 4 region near ADH (LOD = 5.79) strongly influenced liability to alcoholism (P = 1.2 × 10-7, with evidence for pleiotropic effects on P3 (P = 8.5 × 10-4). A region on 6q (LOD = 3.49) had a strong influence on P3 (P = 3.4 × 10-5), with evidence for weaker pleiotropic effects on alcoholism (P = 0.028).

Original languageEnglish (US)
Pages (from-to)495-496
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number6
StatePublished - Nov 6 1998
Externally publishedYes

Fingerprint

Evoked Potentials
Alcoholism
Brain
Diagnostic and Statistical Manual of Mental Disorders
Alcoholics
Chromosomes, Human, Pair 4
Genetic Linkage
International Classification of Diseases
Electrodes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Almasy, L., Williams, J. T., Porjesz, B., Reich, T., Blangero, J., & Begleiter, H. (1998). Pleiotropic genetic influences on event-related brain potentials and alcoholism. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 495-496.

Pleiotropic genetic influences on event-related brain potentials and alcoholism. / Almasy, L.; Williams, J. T.; Porjesz, B.; Reich, T.; Blangero, J.; Begleiter, H.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 81, No. 6, 06.11.1998, p. 495-496.

Research output: Contribution to journalArticle

Almasy, L, Williams, JT, Porjesz, B, Reich, T, Blangero, J & Begleiter, H 1998, 'Pleiotropic genetic influences on event-related brain potentials and alcoholism', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 6, pp. 495-496.
Almasy L, Williams JT, Porjesz B, Reich T, Blangero J, Begleiter H. Pleiotropic genetic influences on event-related brain potentials and alcoholism. American Journal of Medical Genetics - Neuropsychiatric Genetics. 1998 Nov 6;81(6):495-496.
Almasy, L. ; Williams, J. T. ; Porjesz, B. ; Reich, T. ; Blangero, J. ; Begleiter, H. / Pleiotropic genetic influences on event-related brain potentials and alcoholism. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1998 ; Vol. 81, No. 6. pp. 495-496.
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