Pleiotropic effects on subclasses of hdl, adiposity, and glucose metabolism in adult alaskan eskimos

M. Elizabeth Tejero, V. S. Voruganti, Guowen Cai, Shelley A. Cole, Sandra Laston, Charlotte R. Wenger, Jean W. Mac Cluer, Bennet Dyke, Richard Devereux, Sven O. Ebbesson, Richard R. Fabsitz, B. V. Howard, A. G. Comuzzie

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Abstract

The aim of this study was to analyze the heritability and the presence of pleiotropic effects on subfractions of high-density lipoproteins (HDLs) as measured by nuclear magnetic resonance (NMR), parameters for adiposity, and glucose metabolism in adult Alaskan Eskimos. The present family study included 1,214 adult Alaskan Eskimos (537 male/677 female). Body weight, height, circumferences, selected skinfolds, and blood pressure were measured in all participants. Blood samples were collected under fasting conditions for the isolation of plasma. Glucose, insulin, subclasses and size of lipoproteins, triglycerides, total, and HDL cholesterol and lipoprotein (a) were measured in plasma. HbA1c was measured in total blood. Univariate and bivariate quantitative genetic analyses were conducted between HDL subclasses and size and the anthropometric and biochemical measures using the variance decomposition approach. Variation in all the analyzed traits exhibits a significant genetic component. Heritabilities ranged between 0.18±0.11 for LDL2 (intermediate) and 0.89±0.07 for small HDL. No common genetic effects were found on the HDL subclasses (small, intermediate, and large). Small HDL particles were genetically correlated with LDL particles and HbA1c. Negative genetic correlations were observed between intermediate and large HDL subfractions, HDL size and measures of adiposity, and LDL and parameters for glucose metabolism (HbA1, insulin). These observations confirm the presence of possible pleiotropic effects on HDL, adiposity, and cardiovascular risk factors and provide novel insight on the relationship between HDL subclasses, adiposity, and glucose regulation. Am. J. Hum. Biol. 22:444-448, 2010.

Original languageEnglish (US)
Pages (from-to)444-448
Number of pages5
JournalAmerican Journal of Human Biology
Volume22
Issue number4
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Inuits
Eskimos
high density lipoprotein
Adiposity
adiposity
HDL Lipoproteins
glucose
metabolism
Glucose
glycohemoglobin
body weight
blood
social isolation
lipoproteins
heritability
insulin
regulation
Insulin
effect
family studies

ASJC Scopus subject areas

  • Anthropology
  • Anatomy
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

Tejero, M. E., Voruganti, V. S., Cai, G., Cole, S. A., Laston, S., Wenger, C. R., ... Comuzzie, A. G. (2010). Pleiotropic effects on subclasses of hdl, adiposity, and glucose metabolism in adult alaskan eskimos. American Journal of Human Biology, 22(4), 444-448. https://doi.org/10.1002/ajhb.21015

Pleiotropic effects on subclasses of hdl, adiposity, and glucose metabolism in adult alaskan eskimos. / Tejero, M. Elizabeth; Voruganti, V. S.; Cai, Guowen; Cole, Shelley A.; Laston, Sandra; Wenger, Charlotte R.; Mac Cluer, Jean W.; Dyke, Bennet; Devereux, Richard; Ebbesson, Sven O.; Fabsitz, Richard R.; Howard, B. V.; Comuzzie, A. G.

In: American Journal of Human Biology, Vol. 22, No. 4, 07.2010, p. 444-448.

Research output: Contribution to journalArticle

Tejero, ME, Voruganti, VS, Cai, G, Cole, SA, Laston, S, Wenger, CR, Mac Cluer, JW, Dyke, B, Devereux, R, Ebbesson, SO, Fabsitz, RR, Howard, BV & Comuzzie, AG 2010, 'Pleiotropic effects on subclasses of hdl, adiposity, and glucose metabolism in adult alaskan eskimos', American Journal of Human Biology, vol. 22, no. 4, pp. 444-448. https://doi.org/10.1002/ajhb.21015
Tejero, M. Elizabeth ; Voruganti, V. S. ; Cai, Guowen ; Cole, Shelley A. ; Laston, Sandra ; Wenger, Charlotte R. ; Mac Cluer, Jean W. ; Dyke, Bennet ; Devereux, Richard ; Ebbesson, Sven O. ; Fabsitz, Richard R. ; Howard, B. V. ; Comuzzie, A. G. / Pleiotropic effects on subclasses of hdl, adiposity, and glucose metabolism in adult alaskan eskimos. In: American Journal of Human Biology. 2010 ; Vol. 22, No. 4. pp. 444-448.
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