Pleiotropic effects on cardiovascular risk factors within and between the fourth and sixth decades of life: implications for genotype x age interactions.

L. M. Havill, M. C. Mahaney

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We used an approach for detecting genotype x environment interactions to detect and characterize genotype x age interaction in longitudinal measures of three well known cardiovascular risk factors: total plasma cholesterol (TC), systolic blood pressure (SBP), and body weight (Wgt). Our objectives were to determine if the same gene or suite of genes influences quantitative variation in each of these phenotypes in the 4th and 6th decades of life, to assess the impact of additive gene effects in these two decades, and to evaluate the stability of pleiotropic relationships among these phenotypes. Using the Framingham Heart Study data, we constructed two cross-sectional samples comprising individuals on whom these phenotypes were measured at ages 30-39 years (Original Cohort: exam 1, Offspring Cohort: exam 2) and at ages 50-59 years (Original Cohort: exam 11, Offspring Cohort: exam 5). We also constructed a longitudinal sample from the cross-sectional sample members for whom measures on these traits were available at both ages (i.e., 4th and 6th decades of life). Patterns of pleiotropy, inferred from genetic correlations between traits, differ between the two age classes. Further, additive genetic variance in SBP during the 4th decade of life is attributable to a different gene or suite of genes than during the 6th. The magnitude of the effect increases for SBP. Variation in TC and Wgt appear to be influenced by the same gene or genes in both decades. The magnitude of the effect is stable for TC, but increases dramatically with age for Wgt.

Original languageEnglish (US)
Article numberS54
JournalBMC Genetics
Volume4 Suppl 1
StatePublished - 2003
Externally publishedYes

Fingerprint

Genotype
Blood Pressure
Genes
Cholesterol
Phenotype
Genetic Pleiotropy
Weights and Measures
Body Weight

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Pleiotropic effects on cardiovascular risk factors within and between the fourth and sixth decades of life : implications for genotype x age interactions. / Havill, L. M.; Mahaney, M. C.

In: BMC Genetics, Vol. 4 Suppl 1, S54, 2003.

Research output: Contribution to journalArticle

@article{2a73b9b7fbd44e669166fd67cd54ae90,
title = "Pleiotropic effects on cardiovascular risk factors within and between the fourth and sixth decades of life: implications for genotype x age interactions.",
abstract = "We used an approach for detecting genotype x environment interactions to detect and characterize genotype x age interaction in longitudinal measures of three well known cardiovascular risk factors: total plasma cholesterol (TC), systolic blood pressure (SBP), and body weight (Wgt). Our objectives were to determine if the same gene or suite of genes influences quantitative variation in each of these phenotypes in the 4th and 6th decades of life, to assess the impact of additive gene effects in these two decades, and to evaluate the stability of pleiotropic relationships among these phenotypes. Using the Framingham Heart Study data, we constructed two cross-sectional samples comprising individuals on whom these phenotypes were measured at ages 30-39 years (Original Cohort: exam 1, Offspring Cohort: exam 2) and at ages 50-59 years (Original Cohort: exam 11, Offspring Cohort: exam 5). We also constructed a longitudinal sample from the cross-sectional sample members for whom measures on these traits were available at both ages (i.e., 4th and 6th decades of life). Patterns of pleiotropy, inferred from genetic correlations between traits, differ between the two age classes. Further, additive genetic variance in SBP during the 4th decade of life is attributable to a different gene or suite of genes than during the 6th. The magnitude of the effect increases for SBP. Variation in TC and Wgt appear to be influenced by the same gene or genes in both decades. The magnitude of the effect is stable for TC, but increases dramatically with age for Wgt.",
author = "Havill, {L. M.} and Mahaney, {M. C.}",
year = "2003",
language = "English (US)",
volume = "4 Suppl 1",
journal = "BMC Genetics",
issn = "1471-2156",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Pleiotropic effects on cardiovascular risk factors within and between the fourth and sixth decades of life

T2 - implications for genotype x age interactions.

AU - Havill, L. M.

AU - Mahaney, M. C.

PY - 2003

Y1 - 2003

N2 - We used an approach for detecting genotype x environment interactions to detect and characterize genotype x age interaction in longitudinal measures of three well known cardiovascular risk factors: total plasma cholesterol (TC), systolic blood pressure (SBP), and body weight (Wgt). Our objectives were to determine if the same gene or suite of genes influences quantitative variation in each of these phenotypes in the 4th and 6th decades of life, to assess the impact of additive gene effects in these two decades, and to evaluate the stability of pleiotropic relationships among these phenotypes. Using the Framingham Heart Study data, we constructed two cross-sectional samples comprising individuals on whom these phenotypes were measured at ages 30-39 years (Original Cohort: exam 1, Offspring Cohort: exam 2) and at ages 50-59 years (Original Cohort: exam 11, Offspring Cohort: exam 5). We also constructed a longitudinal sample from the cross-sectional sample members for whom measures on these traits were available at both ages (i.e., 4th and 6th decades of life). Patterns of pleiotropy, inferred from genetic correlations between traits, differ between the two age classes. Further, additive genetic variance in SBP during the 4th decade of life is attributable to a different gene or suite of genes than during the 6th. The magnitude of the effect increases for SBP. Variation in TC and Wgt appear to be influenced by the same gene or genes in both decades. The magnitude of the effect is stable for TC, but increases dramatically with age for Wgt.

AB - We used an approach for detecting genotype x environment interactions to detect and characterize genotype x age interaction in longitudinal measures of three well known cardiovascular risk factors: total plasma cholesterol (TC), systolic blood pressure (SBP), and body weight (Wgt). Our objectives were to determine if the same gene or suite of genes influences quantitative variation in each of these phenotypes in the 4th and 6th decades of life, to assess the impact of additive gene effects in these two decades, and to evaluate the stability of pleiotropic relationships among these phenotypes. Using the Framingham Heart Study data, we constructed two cross-sectional samples comprising individuals on whom these phenotypes were measured at ages 30-39 years (Original Cohort: exam 1, Offspring Cohort: exam 2) and at ages 50-59 years (Original Cohort: exam 11, Offspring Cohort: exam 5). We also constructed a longitudinal sample from the cross-sectional sample members for whom measures on these traits were available at both ages (i.e., 4th and 6th decades of life). Patterns of pleiotropy, inferred from genetic correlations between traits, differ between the two age classes. Further, additive genetic variance in SBP during the 4th decade of life is attributable to a different gene or suite of genes than during the 6th. The magnitude of the effect increases for SBP. Variation in TC and Wgt appear to be influenced by the same gene or genes in both decades. The magnitude of the effect is stable for TC, but increases dramatically with age for Wgt.

UR - http://www.scopus.com/inward/record.url?scp=34248657943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248657943&partnerID=8YFLogxK

M3 - Article

C2 - 14975122

AN - SCOPUS:34248657943

VL - 4 Suppl 1

JO - BMC Genetics

JF - BMC Genetics

SN - 1471-2156

M1 - S54

ER -