Platelets in glomerular disease

Jeffrey L. Barnes

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Platelets are viewed as inflammatory cells and play an important role in hemostasis and wound repair. During activation, platelets secrete a wide variety of products that have multiple effects on target cell behavior during tissue remodeling. Among these secretory products are chemotactins, growth factors and fibrogenic substances. This review examines evidence for a role of platelets in glomerular disease and discusses mechanisms of how platelet secretory products may alter permselectivity of the glomerular basement membrane, resulting in enhanced immune complex localization. Also, platelet secretory products may stimulate glomerular remodeling after injury through mechanisms involving cell migration, proliferation and extracellular matrix synthesis, ultimately distorting the normal glomerular architecture and function.

Original languageEnglish (US)
Pages (from-to)378-393
Number of pages16
JournalNephron
Volume77
Issue number4
DOIs
StatePublished - Jan 1 1997

Keywords

  • Extracellular matrix
  • Glomerular permeability
  • Migration
  • Proliferation

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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