Platelets in glomerular disease

Jeffrey L. Barnes

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Platelets are viewed as inflammatory cells and play an important role in hemostasis and wound repair. During activation, platelets secrete a wide variety of products that have multiple effects on target cell behavior during tissue remodeling. Among these secretory products are chemotactins, growth factors and fibrogenic substances. This review examines evidence for a role of platelets in glomerular disease and discusses mechanisms of how platelet secretory products may alter permselectivity of the glomerular basement membrane, resulting in enhanced immune complex localization. Also, platelet secretory products may stimulate glomerular remodeling after injury through mechanisms involving cell migration, proliferation and extracellular matrix synthesis, ultimately distorting the normal glomerular architecture and function.

Original languageEnglish (US)
Pages (from-to)378-393
Number of pages16
JournalNephron
Volume77
Issue number4
StatePublished - 1997

Fingerprint

Blood Platelets
Glomerular Basement Membrane
Wounds and Injuries
Antigen-Antibody Complex
Hemostasis
Cell Movement
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Cell Proliferation

Keywords

  • Extracellular matrix
  • Glomerular permeability
  • Migration
  • Proliferation

ASJC Scopus subject areas

  • Nephrology

Cite this

Barnes, J. L. (1997). Platelets in glomerular disease. Nephron, 77(4), 378-393.

Platelets in glomerular disease. / Barnes, Jeffrey L.

In: Nephron, Vol. 77, No. 4, 1997, p. 378-393.

Research output: Contribution to journalArticle

Barnes, JL 1997, 'Platelets in glomerular disease', Nephron, vol. 77, no. 4, pp. 378-393.
Barnes JL. Platelets in glomerular disease. Nephron. 1997;77(4):378-393.
Barnes, Jeffrey L. / Platelets in glomerular disease. In: Nephron. 1997 ; Vol. 77, No. 4. pp. 378-393.
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