Platelet transfusion

Michael Adam Meledeo, Kimberly A. Thomas, James A. Bynum, Kristin M. Reddoch-Cardenas, Todd M. Getz, Heather F. Pidcoke, Philip C. Spinella, Andrew P. Cap

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Platelet (PLT) biology is deceptively complicated. From a morphological aspect, the elegant discoid shape of the resting platelet belies the intricate cytoskeleton and convoluted tubular systems that enable spectacular shape change upon activation. The evolution of platelet products and their use in transfusion is similarly convoluted and requires immersion in history to understand. As described below, the current state of the art in platelet transfusion rests on surprisingly little robust clinical data, minimal efforts to tailor product characteristics to patient needs, and a regulatory framework that does not facilitate optimizing platelet function. Development of new platelet products and optimal transfusion strategies for bleeding patients represent opportunities for major advances in the care of bleeding patients or those at high risk of bleeding.

Original languageEnglish (US)
Title of host publicationTrauma Induced Coagulopathy
PublisherSpringer
Pages391-428
Number of pages38
ISBN (Electronic)9783030536060
ISBN (Print)9783030536053
DOIs
StatePublished - Oct 12 2020
Externally publishedYes

Keywords

  • Blood banking
  • Hemostasis
  • Platelet function
  • Platelet transfusion
  • Storage lesion
  • Trauma
  • Trauma-induced coagulopathy
  • Whole blood

ASJC Scopus subject areas

  • General Medicine

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