Abstract
The density of serotonin reuptake receptors on peripheral platelets from 22 patients with primary fibromyalgia syndrome (FS) and the serum serotonin concentrations in 9 patients with FS were compared with those of matched healthy controls. The mean serum serotonin concentration was lower (p = 0.01) in FS than in controls, while the binding of 3H-imipramine was higher (p = 0.035) and normalized with treatment using a combination of ibuprofen and alprazolam. Improvement in selected clinical measures of FS disease activity during treatment correlated with the change in platelet 3H-imipramine binding. These findings support the proposed hypothesis of aberrant pain perception in FS resulting from a deficiency of serotonin.
Original language | English (US) |
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Pages (from-to) | 104-109 |
Number of pages | 6 |
Journal | Journal of Rheumatology |
Volume | 19 |
Issue number | 1 |
State | Published - 1992 |
Keywords
- fibromyalgia
- fibrositis
- imipramine
- monoamine oxidase
- platelets
- serotonin
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology