Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome

I. J. Russell, J. E. Michalek, G. A. Vipraio, E. M. Fletcher, M. A. Javors, C. A. Bowden

Research output: Contribution to journalArticlepeer-review

226 Scopus citations

Abstract

The density of serotonin reuptake receptors on peripheral platelets from 22 patients with primary fibromyalgia syndrome (FS) and the serum serotonin concentrations in 9 patients with FS were compared with those of matched healthy controls. The mean serum serotonin concentration was lower (p = 0.01) in FS than in controls, while the binding of 3H-imipramine was higher (p = 0.035) and normalized with treatment using a combination of ibuprofen and alprazolam. Improvement in selected clinical measures of FS disease activity during treatment correlated with the change in platelet 3H-imipramine binding. These findings support the proposed hypothesis of aberrant pain perception in FS resulting from a deficiency of serotonin.

Original languageEnglish (US)
Pages (from-to)104-109
Number of pages6
JournalJournal of Rheumatology
Volume19
Issue number1
StatePublished - Jan 1 1992

Keywords

  • fibromyalgia
  • fibrositis
  • imipramine
  • monoamine oxidase
  • platelets
  • serotonin

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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