Platelet serotonin uptake is higher in early-onset than in late-onset alcoholics

Martin Javors, Mohamed Tiouririne, Thomas Prihoda

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The main objective of this study was to compare platelet serotonin (5-HT) uptake between early-onset alcoholics (EOA) and late-onset alcoholics (LOA). Subjects were 24 dependent male alcoholic in-patients and 21 healthy control subjects. 5-HT uptake was quantified by incubating platelets with [3H]5-HT at various concentrations (0.5 to 1000 nM). 5-HT uptake was higher in EOA, compared to both the LOA and control groups (P < 0.02) at the highest 5-HT concentration (1000 nM). No significant difference was found between LOA and controls or between EOA + LOA and controls. Previous studies have shown that 5-HT uptake was higher in platelets, lymphocytes, and brain of alcoholics vs controls, but our data suggest that higher platelet serotonin transporter function is limited to EOA, not LOA.

Original languageEnglish (US)
Pages (from-to)390-393
Number of pages4
JournalAlcohol and Alcoholism
Volume35
Issue number4
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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