TY - JOUR
T1 - Platelet serotonin uptake is higher in early-onset than in late-onset alcoholics
AU - Javors, Martin
AU - Tiouririne, Mohamed
AU - Prihoda, Thomas
PY - 2000
Y1 - 2000
N2 - The main objective of this study was to compare platelet serotonin (5-HT) uptake between early-onset alcoholics (EOA) and late-onset alcoholics (LOA). Subjects were 24 dependent male alcoholic in-patients and 21 healthy control subjects. 5-HT uptake was quantified by incubating platelets with [3H]5-HT at various concentrations (0.5 to 1000 nM). 5-HT uptake was higher in EOA, compared to both the LOA and control groups (P < 0.02) at the highest 5-HT concentration (1000 nM). No significant difference was found between LOA and controls or between EOA + LOA and controls. Previous studies have shown that 5-HT uptake was higher in platelets, lymphocytes, and brain of alcoholics vs controls, but our data suggest that higher platelet serotonin transporter function is limited to EOA, not LOA.
AB - The main objective of this study was to compare platelet serotonin (5-HT) uptake between early-onset alcoholics (EOA) and late-onset alcoholics (LOA). Subjects were 24 dependent male alcoholic in-patients and 21 healthy control subjects. 5-HT uptake was quantified by incubating platelets with [3H]5-HT at various concentrations (0.5 to 1000 nM). 5-HT uptake was higher in EOA, compared to both the LOA and control groups (P < 0.02) at the highest 5-HT concentration (1000 nM). No significant difference was found between LOA and controls or between EOA + LOA and controls. Previous studies have shown that 5-HT uptake was higher in platelets, lymphocytes, and brain of alcoholics vs controls, but our data suggest that higher platelet serotonin transporter function is limited to EOA, not LOA.
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U2 - 10.1093/alcalc/35.4.390
DO - 10.1093/alcalc/35.4.390
M3 - Article
C2 - 10906007
AN - SCOPUS:0033852703
SN - 0735-0414
VL - 35
SP - 390
EP - 393
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
IS - 4
ER -