Platelet monoamine oxidase response to lithium treatment in psychiatric patients

L. G. Huang, C. L. Bowden

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term outcome in schizophrenic patients. Change in MAO was not correlated with lithium dosage or plasma levels. Patients with baseline MAO values below the median had the largest activity increases. Platelet MAO might thus be characterized as a state variable, increased by lithium as a nonspecific pharmacologic effect, with the increase associated with poor clinical outcome in manic patients.

Original languageEnglish (US)
Pages (from-to)326-331
Number of pages6
JournalJournal of Clinical Psychopharmacology
Volume4
Issue number6
StatePublished - 1984

Fingerprint

Monoamine Oxidase
Lithium
Psychiatry
Blood Platelets
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Platelet monoamine oxidase response to lithium treatment in psychiatric patients. / Huang, L. G.; Bowden, C. L.

In: Journal of Clinical Psychopharmacology, Vol. 4, No. 6, 1984, p. 326-331.

Research output: Contribution to journalArticle

@article{d9585f88f20f4f4ab2a1ecdc7e01debd,
title = "Platelet monoamine oxidase response to lithium treatment in psychiatric patients",
abstract = "Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term outcome in schizophrenic patients. Change in MAO was not correlated with lithium dosage or plasma levels. Patients with baseline MAO values below the median had the largest activity increases. Platelet MAO might thus be characterized as a state variable, increased by lithium as a nonspecific pharmacologic effect, with the increase associated with poor clinical outcome in manic patients.",
author = "Huang, {L. G.} and Bowden, {C. L.}",
year = "1984",
language = "English (US)",
volume = "4",
pages = "326--331",
journal = "Journal of Clinical Psychopharmacology",
issn = "0271-0749",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Platelet monoamine oxidase response to lithium treatment in psychiatric patients

AU - Huang, L. G.

AU - Bowden, C. L.

PY - 1984

Y1 - 1984

N2 - Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term outcome in schizophrenic patients. Change in MAO was not correlated with lithium dosage or plasma levels. Patients with baseline MAO values below the median had the largest activity increases. Platelet MAO might thus be characterized as a state variable, increased by lithium as a nonspecific pharmacologic effect, with the increase associated with poor clinical outcome in manic patients.

AB - Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term outcome in schizophrenic patients. Change in MAO was not correlated with lithium dosage or plasma levels. Patients with baseline MAO values below the median had the largest activity increases. Platelet MAO might thus be characterized as a state variable, increased by lithium as a nonspecific pharmacologic effect, with the increase associated with poor clinical outcome in manic patients.

UR - http://www.scopus.com/inward/record.url?scp=0021680857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021680857&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 326

EP - 331

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

SN - 0271-0749

IS - 6

ER -