Platelet immunoregulatory factors

Mark L. Tykocinski, Na Xiong, Dwight M. Morrow

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A number of soluble and membrane-associated proteins are known to mediate platelet:leukocyte interactions. Platelet-derived factors that have attracted the most attention to date include transforming growth factor β, interleukin 1 and platelet factor 4. Recently, we have uncovered another protein within platelets that has leukocyte modulatory activity. It was previously characterized as an endometrial glycoprotein named placental protein 14 (PP14) with suppressive effects upon lymphocyte proliferation, pro-inflammatory cytokine production and natural killer cell function. The "hemalopoietic" PP14 derived from cells of the megakaryocytic lineage shares this immunosuppressive property, as evaluated by two-way mixed lymphocyte cultures. Interestingly, two alternatively spliced hematopoietic PP14 mRNAs have been cloned which differ in their encoded proteins. Cell-free translation and transfection analyses have verified the translatability of both PP14 mRNA species and allowed for the analysis of their glycosylation properties. PP14, a member of the lipocalin structural superfamily of proteins, now offers an intriguing new link between the coagulation and immune systems.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalStem Cells
Volume14
Issue numberSUPPL. 1
DOIs
StatePublished - 1996

Keywords

  • Anti-inflammatory cytokines
  • Immunoregulation
  • Lipocalins

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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