Platelet adenylate cyclase responses in depression: Implications for a receptor defect

Yao Chun Wang, Ghanshyam N. Pandey, Joe Mendels, Alan Frazer

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The dose-dependent stimulatory response of prostaglandin E1 (PGE1) on the net synthesis of 3H-adenosine 3′,5′-monophosphate (cyclic AMP) in platelets whose adenine nucleotide pools had been labelled by prior incubation with 3H-adenine was measured. Also, the dose-dependent inhibition produced by norepinephrine (NE) on this stimulatory process was evaluated. Platelets were obtained from eleven moderately depressed male patients and from eight non-depressed normal male control subjects. No difference was noted between the two groups of subjects either in the stimulation produced by PGE1 or in the inhibition caused by NE. Subdividing the patients into different subgroups (e.g., bipolar or unipolar) did not produce any significant differences. This finding suggests that there is no generalized defect in alpha adrenergic responses in depressed male patients.

Original languageEnglish (US)
Pages (from-to)291-300
Number of pages10
JournalPsychopharmacologia
Volume36
Issue number4
DOIs
StatePublished - Dec 1 1974
Externally publishedYes

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Keywords

  • Adenylate Cyclase
  • Depression
  • Norepinephrine
  • Platelet
  • Prostaglandin E

ASJC Scopus subject areas

  • Pharmacology

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