Platelet-activating factor antagonists and implantation in rabbits

C. J. Norris, W. A. Peairs, G. B. Kudolo, E. R. Newton, M. J K Harper

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In an initial experiment, rabbits were injected i.v. with a platelet-activating factor (PAF) antagonist CV-3988 twice a day on days 5 and 6 of pregnancy. Some inhibition of implantation was observed. This effect could not be reproduced in subsequent experiments at the same or at larger or smaller doses. The non-metabolized analogue of PAF, N-carbamyl-PAF (C-PAF) had an inhibitory effect on implantation only when given at toxic concentrations. When CV-3988 and C-PAF were given together on days 5 and 6, there was no effect on implantation. None of the other PAF antagonists tested - BN52021, SR163,441, WEB2086 or TCV-309 - at various doses could inhibit implantation when given on the same days of pregnancy. TCV-309, at 0.1 mg kg-1 i.v. given on days 2-4 of pregnancy, was also ineffective. These results provide no clear support for a role of PAF in implantation in rabbits.

Original languageEnglish (US)
Pages (from-to)395-401
Number of pages7
JournalJournal of Reproduction and Fertility
Volume100
Issue number2
StatePublished - 1994
Externally publishedYes

Fingerprint

Platelet Activating Factor
Rabbits
WEB 2086
Pregnancy
Poisons
CV 3988
TCV 309

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Physiology
  • Embryology
  • Obstetrics and Gynecology

Cite this

Norris, C. J., Peairs, W. A., Kudolo, G. B., Newton, E. R., & Harper, M. J. K. (1994). Platelet-activating factor antagonists and implantation in rabbits. Journal of Reproduction and Fertility, 100(2), 395-401.

Platelet-activating factor antagonists and implantation in rabbits. / Norris, C. J.; Peairs, W. A.; Kudolo, G. B.; Newton, E. R.; Harper, M. J K.

In: Journal of Reproduction and Fertility, Vol. 100, No. 2, 1994, p. 395-401.

Research output: Contribution to journalArticle

Norris, CJ, Peairs, WA, Kudolo, GB, Newton, ER & Harper, MJK 1994, 'Platelet-activating factor antagonists and implantation in rabbits', Journal of Reproduction and Fertility, vol. 100, no. 2, pp. 395-401.
Norris CJ, Peairs WA, Kudolo GB, Newton ER, Harper MJK. Platelet-activating factor antagonists and implantation in rabbits. Journal of Reproduction and Fertility. 1994;100(2):395-401.
Norris, C. J. ; Peairs, W. A. ; Kudolo, G. B. ; Newton, E. R. ; Harper, M. J K. / Platelet-activating factor antagonists and implantation in rabbits. In: Journal of Reproduction and Fertility. 1994 ; Vol. 100, No. 2. pp. 395-401.
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