Plasmodium falciparum genetic crosses in a humanized mouse model

Ashley M. Vaughan, Richard S. Pinapati, Ian H. Cheeseman, Nelly Camargo, Matthew Fishbaugher, Lisa A. Checkley, Shalini Nair, Carolyn A. Hutyra, François H. Nosten, Timothy J.C. Anderson, Michael T. Ferdig, Stefan H.I. Kappe

    Research output: Contribution to journalArticlepeer-review

    36 Scopus citations

    Abstract

    Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.

    Original languageEnglish (US)
    Pages (from-to)631-633
    Number of pages3
    JournalNature Methods
    Volume12
    Issue number7
    DOIs
    StatePublished - Jun 30 2015

    ASJC Scopus subject areas

    • Biotechnology
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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