Plasminogen deficiency as a rare cause of conjunctivitis and lymphadenopathy

Sophia L. Yohe, Marcos Reyes, Daniel A. Johnson, Constance L. Fry, Frank W. Scribbick, Marsha C. Kinney

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Plasminogen deficiency is a rare disorder complicated by the subsequent formation of firm "woody" plaques in the eye (ligneous conjunctivitis) or other mucosal sites as the result of inflammation or trauma. The plaques are composed of fibrinogen, granulation tissue, and inflammatory cells. The findings may be considered nonspecific by the unsuspecting surgical pathologist and delay the appropriate diagnosis. We report the first case of lymph node involvement with characteristic eosinophilic hyaline deposits that are periodic acid Schiff positive, stain dark red with Masson trichrome, and contain fibrinogen as detected by immunofluorescence and describe the longitudinal evolution of this patient's disease over a 15-year period. The differential diagnosis of amorphous hyaline material in lymph node biopsies is discussed.

Original languageEnglish (US)
Pages (from-to)313-319
Number of pages7
JournalAmerican Journal of Surgical Pathology
Issue number2
StatePublished - Feb 2009


  • Ligneous conjunctivitis
  • Lymph node
  • Plasminogen deficiency

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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