Plasmenylethanolamine: growth factor for cholesterol-reducing Eubacterium

G. E. Mott, A. W. Brinkley

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A plasmalogen, plasmenylethanolamine, is required for in vitro growth of strains of Eubacterium which convert cholesterol to coprostanol. Plasmenyl-ethanolamine was isolated from calf brain by selective saponification of lipid fractions separated by thin-layer or column chromatography. Cholesterol-containing thioglycolate broth plus purified plasmenylethanolamine or its 2-lyso derivative supported growth of Eubacterium ATCC 21408 and a cholesterol-reducing Eubacterium isolated from baboon feces. Plasmenylethanolamine obtained from commercial sources also supported growth of these organisms, but none of a number of other pure lipids would support growth. Metabolism of the alkenyl ether group of plasmenylethanolamine occurred during growth.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalJournal of bacteriology
Volume139
Issue number3
StatePublished - 1979

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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