Plasmapheresis in the Treatment of Stiff-Man Syndrome

A. M. Vicari; F. Folli; G. Pozza; G. C. Comi; M. Comola; N. Canal; C. Besana; A. Borri; M. Tresoldi; M. Solimena; P. Decamilli

doi:10.1056/NEJM198906013202220

Plasmapheresis in the Treatment of Stiff-Man Syndrome

A. M. Vicari, F. Folli, G. Pozza, G. C. Comi, M. Comola, N. Canal, C. Besana, A. Borri, M. Tresoldi, M. Solimena, P. Decamilli

Medicine

Research output: Contribution to journal › Letter

82 Scopus citations

Abstract

To the Editor: We have previously reported¹ the presence of antibodies against glutamic acid decarboxylase in the serum and cerebrospinal fluid of a patient with stiff-man syndrome associated with type Ib diabetes mellitus and epilepsy. In February 1988 the patient was readmitted to our department for the occurrence in the preceding month of several episodes of diffuse muscular stiffness associated with apnea that were only partially relieved by intravenous diazepam (20 mg). On admission, the patient had the typical clinical and electromyographic features of stiff-man syndrome and was confined to bed. The presence of autoantibodies to glutamic acid decarboxylase was…

Original language	English (US)
Number of pages	1
Journal	New England Journal of Medicine
Volume	320
Issue number	22
DOIs	https://doi.org/10.1056/NEJM198906013202220
State	Published - Jun 1 1989

ASJC Scopus subject areas

Medicine(all)

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Vicari, A. M., Folli, F., Pozza, G., Comi, G. C., Comola, M., Canal, N., Besana, C., Borri, A., Tresoldi, M., Solimena, M., & Decamilli, P. (1989). Plasmapheresis in the Treatment of Stiff-Man Syndrome. New England Journal of Medicine, 320(22). https://doi.org/10.1056/NEJM198906013202220

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abstract = "To the Editor: We have previously reported1 the presence of antibodies against glutamic acid decarboxylase in the serum and cerebrospinal fluid of a patient with stiff-man syndrome associated with type Ib diabetes mellitus and epilepsy. In February 1988 the patient was readmitted to our department for the occurrence in the preceding month of several episodes of diffuse muscular stiffness associated with apnea that were only partially relieved by intravenous diazepam (20 mg). On admission, the patient had the typical clinical and electromyographic features of stiff-man syndrome and was confined to bed. The presence of autoantibodies to glutamic acid decarboxylase was…",

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T1 - Plasmapheresis in the Treatment of Stiff-Man Syndrome

AU - Vicari, A. M.

AU - Folli, F.

AU - Pozza, G.

AU - Comi, G. C.

AU - Comola, M.

AU - Canal, N.

AU - Besana, C.

AU - Borri, A.

AU - Tresoldi, M.

AU - Solimena, M.

AU - Decamilli, P.

PY - 1989/6/1

Y1 - 1989/6/1

N2 - To the Editor: We have previously reported1 the presence of antibodies against glutamic acid decarboxylase in the serum and cerebrospinal fluid of a patient with stiff-man syndrome associated with type Ib diabetes mellitus and epilepsy. In February 1988 the patient was readmitted to our department for the occurrence in the preceding month of several episodes of diffuse muscular stiffness associated with apnea that were only partially relieved by intravenous diazepam (20 mg). On admission, the patient had the typical clinical and electromyographic features of stiff-man syndrome and was confined to bed. The presence of autoantibodies to glutamic acid decarboxylase was…

AB - To the Editor: We have previously reported1 the presence of antibodies against glutamic acid decarboxylase in the serum and cerebrospinal fluid of a patient with stiff-man syndrome associated with type Ib diabetes mellitus and epilepsy. In February 1988 the patient was readmitted to our department for the occurrence in the preceding month of several episodes of diffuse muscular stiffness associated with apnea that were only partially relieved by intravenous diazepam (20 mg). On admission, the patient had the typical clinical and electromyographic features of stiff-man syndrome and was confined to bed. The presence of autoantibodies to glutamic acid decarboxylase was…

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