Plasmapheresis in the Treatment of Stiff-Man Syndrome

A. M. Vicari, F. Folli, G. Pozza, G. C. Comi, M. Comola, N. Canal, C. Besana, A. Borri, M. Tresoldi, M. Solimena, P. Decamilli

Research output: Contribution to journalLetterpeer-review

83 Scopus citations


To the Editor: We have previously reported1 the presence of antibodies against glutamic acid decarboxylase in the serum and cerebrospinal fluid of a patient with stiff-man syndrome associated with type Ib diabetes mellitus and epilepsy. In February 1988 the patient was readmitted to our department for the occurrence in the preceding month of several episodes of diffuse muscular stiffness associated with apnea that were only partially relieved by intravenous diazepam (20 mg). On admission, the patient had the typical clinical and electromyographic features of stiff-man syndrome and was confined to bed. The presence of autoantibodies to glutamic acid decarboxylase was…

Original languageEnglish (US)
Pages (from-to)1499
Number of pages1
JournalNew England Journal of Medicine
Issue number22
StatePublished - Jun 1 1989

ASJC Scopus subject areas

  • Medicine(all)


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