Plasma vasopressin concentration in high sodium renal hypertension

Carmen Hinojosa, Robert E. Shade, Joseph R. Haywood

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations

    Abstract

    One-kidney, figure-8 renal wrapped and sham-operated rats maintained on high sodium intake were studied to determine plasma concentrations of vasopressin during the onset of hypertension. Animals were chronically prepared with femoral artery and vein catheters. Arterial blood samples were taken from conscious rats before and 3 days after renal wrap or sham operation while donor blood was simultaneously infused intravenously. Three days after surgery, arterial pressure, plasma osmolality and plasma vasopressin concentration increased significantly in the renal wrapped animals and remained unchanged in the sham-operated rats. Ganglionic blockade with hexamethonium and atropine produced equivalent decreases in arterial pressure and increases in plasma vasopressin concentration in the two groups of rats. Subsequent administration of the V1vasopressin antagonist, d(CH2)5Tyr(Me)AVP, caused a significantly greater fall in arterial pressure in the hypertensive rats. These results provide further evidence for a contribution of vasopressin to sodium-dependent hypertension.

    Original languageEnglish (US)
    Pages (from-to)529-534
    Number of pages6
    JournalJournal of Hypertension
    Volume4
    Issue number5
    DOIs
    StatePublished - Oct 1986

    Keywords

    • Arterial pressure
    • Figure-8 hypertension
    • Ganglionic blockade
    • One-kidney
    • V vasopressin antagonist
    • Vasopressin

    ASJC Scopus subject areas

    • Internal Medicine
    • Physiology
    • Cardiology and Cardiovascular Medicine

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