@article{3d19ed2a704b4900bf5a2cdd85333247,
title = "Plasma total-tau as a biomarker of stroke risk in the community",
abstract = "Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.",
author = "Pase, {Matthew P.} and Himali, {Jayandra J.} and Aparicio, {Hugo J.} and Romero, {Jose Rafael} and Satizabal, {Claudia L.} and Pauline Maillard and Charles DeCarli and Beiser, {Alexa S.} and Sudha Seshadri",
note = "Funding Information: M.P.P. is funded by a National Heart Foundation of Australia Future Leader Fellowship (102052). The Framingham Heart Study is supported by the National Heart, Lung, and Blood Institute (contracts N01-HC-25195 and HHSN268201500001I) and by grants from the National Institute on Aging (R01 AG0059421, R01 AG054076, R01 AG049607, R01 AG058589, R01 AG059421, U01 AG049505, and U01 AG052409) and the National Institute of Neurological Disorders and Stroke (NS017950 and UH2 NS100605). H.J.A. is supported by a National Institute on Aging Research Supplement to Promote Diversity in Health-Related Research (R01AG054076-02S1) and through support from Boston University School of Medicine's Jack Spivack Neuroscience Scholarship and Aram V. Chobanian Assistant Professorship. We thank the FHS participants for donating their time to our research; and P. Sutherland and S. Blease of the FHS for their assistance. Publisher Copyright: {\textcopyright} 2019 American Neurological Association",
year = "2019",
month = sep,
doi = "10.1002/ana.25542",
language = "English (US)",
volume = "86",
pages = "463--467",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",
}