Abstract
Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 463-467 |
| Number of pages | 5 |
| Journal | Annals of neurology |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2019 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
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Pase, M. P., Himali, J. J., Aparicio, H. J., Romero, J. R., Satizabal, C. L., Maillard, P., DeCarli, C., Beiser, A. S., & Seshadri, S. (2019). Plasma total-tau as a biomarker of stroke risk in the community. Annals of neurology, 86(3), 463-467. https://doi.org/10.1002/ana.25542