Plasma protein biomarkers of the geriatric syndrome of frailty

Kayla Darvin, Amanda Randolph, Symphony Ovalles, Dipti Halade, Leah Breeding, Arlan Richardson, Sara E. Espinoza

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Frailty is a geriatric syndrome associated with physical decline with aging. Using a proteomics-based screening method to screen plasma for potential biomarkers, we previously found infammatory glycoproteins to be increased with frailty. The purpose of this study was to confrm if plasma levels of these glycoproteins, as well as of interleukin-6, are increased with frailty in a larger sample (n = 65) of community-dwelling older adults. Plasma levels of transferrin, fbrinogen, haptoglobin, and interleukin-6 were determined with enzyme-linked immunosorbent assay. Differences in protein concentrations by frailty status were determined using analysis of variance. Higher levels of transferrin (p <.001), fbrinogen (p <.0001), and interleukin-6 (p =.0035) were associated with frailty status (nonfrail, prefrail, or frail) and frailty score (0-5) in this sample even after adjustment for age and sex. Haptoglobin did not differ by frailty status (p =.05). Our fndings largely confrmed the fndings of our nontargeted approach that infammatory glycoproteins are increased with frailty. Future studies should include larger examinations of these associations and consider the potential usefulness of these glycoproteins as biomarkers for frailty.

Original languageEnglish (US)
Pages (from-to)182-186
Number of pages5
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume69 A
Issue number2
DOIs
StatePublished - Mar 17 2014

Keywords

  • Biomarkers
  • Frailty

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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