TY - JOUR
T1 - Plasma protein biomarkers of the geriatric syndrome of frailty
AU - Darvin, Kayla
AU - Randolph, Amanda
AU - Ovalles, Symphony
AU - Halade, Dipti
AU - Breeding, Leah
AU - Richardson, Arlan
AU - Espinoza, Sara E.
N1 - Funding Information:
Funding This work was supported by Veterans Affairs Research & Development (VISN 17 New Investigator Award, #10N17), the San Antonio Area Foundation, the Biomedical Foundation of South Texas, The University Research Council of the University of Texas Health Science Center at San Antonio, The Harold Amos Medical Faculty Development Program with the Robert Wood Johnson Foundation, and Clinical Translational Science Award Number KL2 RR025766 from the National Center for Research Resources. This material is the result of work supported with resources and the use of facilities at the Audie Murphy VA Medical Center, San Antonio, TX.
PY - 2014
Y1 - 2014
N2 - Frailty is a geriatric syndrome associated with physical decline with aging. Using a proteomics-based screening method to screen plasma for potential biomarkers, we previously found infammatory glycoproteins to be increased with frailty. The purpose of this study was to confrm if plasma levels of these glycoproteins, as well as of interleukin-6, are increased with frailty in a larger sample (n = 65) of community-dwelling older adults. Plasma levels of transferrin, fbrinogen, haptoglobin, and interleukin-6 were determined with enzyme-linked immunosorbent assay. Differences in protein concentrations by frailty status were determined using analysis of variance. Higher levels of transferrin (p <.001), fbrinogen (p <.0001), and interleukin-6 (p =.0035) were associated with frailty status (nonfrail, prefrail, or frail) and frailty score (0-5) in this sample even after adjustment for age and sex. Haptoglobin did not differ by frailty status (p =.05). Our fndings largely confrmed the fndings of our nontargeted approach that infammatory glycoproteins are increased with frailty. Future studies should include larger examinations of these associations and consider the potential usefulness of these glycoproteins as biomarkers for frailty.
AB - Frailty is a geriatric syndrome associated with physical decline with aging. Using a proteomics-based screening method to screen plasma for potential biomarkers, we previously found infammatory glycoproteins to be increased with frailty. The purpose of this study was to confrm if plasma levels of these glycoproteins, as well as of interleukin-6, are increased with frailty in a larger sample (n = 65) of community-dwelling older adults. Plasma levels of transferrin, fbrinogen, haptoglobin, and interleukin-6 were determined with enzyme-linked immunosorbent assay. Differences in protein concentrations by frailty status were determined using analysis of variance. Higher levels of transferrin (p <.001), fbrinogen (p <.0001), and interleukin-6 (p =.0035) were associated with frailty status (nonfrail, prefrail, or frail) and frailty score (0-5) in this sample even after adjustment for age and sex. Haptoglobin did not differ by frailty status (p =.05). Our fndings largely confrmed the fndings of our nontargeted approach that infammatory glycoproteins are increased with frailty. Future studies should include larger examinations of these associations and consider the potential usefulness of these glycoproteins as biomarkers for frailty.
KW - Biomarkers
KW - Frailty
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U2 - 10.1093/gerona/glt183
DO - 10.1093/gerona/glt183
M3 - Article
C2 - 24285743
AN - SCOPUS:84896769888
SN - 1079-5006
VL - 69 A
SP - 182
EP - 186
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 2
ER -