Plasma lipidomic profile signature of hypertension in mexican american families

Specific role of diacylglycerols

Hemant Kulkarni, Peter J. Meikle, Manju Mamtani, Jacquelyn M. Weir, Christopher K. Barlow, Jeremy B. Jowett, Claire Bellis, Thomas D. Dyer, Matthew P. Johnson, David L. Rainwater, Laura Almasy, Michael C. Mahaney, Anthony G. Comuzzie, John Blangero, Joanne E. Curran

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Both as a component of metabolic syndrome and as an independent entity, hypertension poses a continued challenge with regard to its diagnosis, pathogenesis, and treatment. Previous studies have documented connections between hypertension and indicators of lipid metabolism. Novel technologies, such as plasma lipidomic profiling, promise a better understanding of disorders in which there is a derangement of the lipid metabolism. However, association of plasma lipidomic profiles with hypertension in a high-risk population, such as Mexican Americans, has not been evaluated before. Using the rich data and sample resource from the ongoing San Antonio Family Heart Study, we conducted plasma lipidomic profiling by combining high-performance liquid chromatography with tandem mass spectroscopy to characterize 319 lipid species in 1192 individuals from 42 large and extended Mexican American families. Robust statistical analyses using polygenic regression models, liability threshold models, and bivariate trait analyses implemented in the SOLAR software were conducted after accounting for obesity, insulin resistance, and relative abundance of various lipoprotein fractions. Diacylglycerols, in general, and the DG 16:0/22:5 and DG 16:0/22:6 lipid species, in particular, were significantly associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), as well as liability of incident hypertension measured during 7140.17 person-years of follow-up. Four lipid species, including the DG 16:0/22:5 and DG 16:0/22:6 species, showed significant genetic correlations with the liability of hypertension in bivariate trait analyses. Our results demonstrate the value of plasma lipidomic profiling in the context of hypertension and identify disturbance of diacylglycerol metabolism as an independent biomarker of hypertension.

Original languageEnglish (US)
Pages (from-to)621-626
Number of pages6
JournalHypertension
Volume62
Issue number3
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Diglycerides
Hypertension
Blood Pressure
Lipids
Lipid Metabolism
Lipoproteins
Insulin Resistance
Mass Spectrometry
Arterial Pressure
Software
Obesity
Biomarkers
High Pressure Liquid Chromatography
Technology
Population

Keywords

  • blood pressure
  • hypertension
  • lipid species
  • lipidomics
  • Mexican Americans

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Kulkarni, H., Meikle, P. J., Mamtani, M., Weir, J. M., Barlow, C. K., Jowett, J. B., ... Curran, J. E. (2013). Plasma lipidomic profile signature of hypertension in mexican american families: Specific role of diacylglycerols. Hypertension, 62(3), 621-626. https://doi.org/10.1161/HYPERTENSIONAHA.113.01396

Plasma lipidomic profile signature of hypertension in mexican american families : Specific role of diacylglycerols. / Kulkarni, Hemant; Meikle, Peter J.; Mamtani, Manju; Weir, Jacquelyn M.; Barlow, Christopher K.; Jowett, Jeremy B.; Bellis, Claire; Dyer, Thomas D.; Johnson, Matthew P.; Rainwater, David L.; Almasy, Laura; Mahaney, Michael C.; Comuzzie, Anthony G.; Blangero, John; Curran, Joanne E.

In: Hypertension, Vol. 62, No. 3, 09.2013, p. 621-626.

Research output: Contribution to journalArticle

Kulkarni, H, Meikle, PJ, Mamtani, M, Weir, JM, Barlow, CK, Jowett, JB, Bellis, C, Dyer, TD, Johnson, MP, Rainwater, DL, Almasy, L, Mahaney, MC, Comuzzie, AG, Blangero, J & Curran, JE 2013, 'Plasma lipidomic profile signature of hypertension in mexican american families: Specific role of diacylglycerols', Hypertension, vol. 62, no. 3, pp. 621-626. https://doi.org/10.1161/HYPERTENSIONAHA.113.01396
Kulkarni, Hemant ; Meikle, Peter J. ; Mamtani, Manju ; Weir, Jacquelyn M. ; Barlow, Christopher K. ; Jowett, Jeremy B. ; Bellis, Claire ; Dyer, Thomas D. ; Johnson, Matthew P. ; Rainwater, David L. ; Almasy, Laura ; Mahaney, Michael C. ; Comuzzie, Anthony G. ; Blangero, John ; Curran, Joanne E. / Plasma lipidomic profile signature of hypertension in mexican american families : Specific role of diacylglycerols. In: Hypertension. 2013 ; Vol. 62, No. 3. pp. 621-626.
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