Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Hemant Kulkarni, Peter J. Meikle, Manju Mamtani, Jacquelyn M. Weir, Marcio Almeida, Vincent Diego, Juan Manuel Peralta, Christopher K. Barlow, Claire Bellis, Thomas D. Dyer, Laura Almasy, Michael C. Mahaney, Anthony G. Comuzzie, Harald H H Göring, Joanne E. Curran, John Blangero

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the highresolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic influences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22% of variability in the homeostatic model of assessment-insulin resistance trait and 16% to 22% variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in MS. - Kulkarni, H., P. J. Meikle, M. Mamtani, J. M. Weir, M. Almeida, V. Diego, J. M. Peralta, C. K. Barlow, C. Bellis, T. D. Dyer, L. Almasy, M. C. Mahaney, A. G. Comuzzie, H. H. H. Göring, J. E. Curran, and J. Blangero. Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. J. Lipid Res . 2014. 55: 939-946.

Original languageEnglish (US)
Pages (from-to)939-946
Number of pages8
JournalJournal of Lipid Research
Volume55
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Plasmas
Insulin
Family Relations
Waist Circumference
Principal Component Analysis
Principal component analysis
HDL Cholesterol
Insulin Resistance
Chronic Disease
Software
Obesity
Cholesterol
Lipids
Glucose
Serum

Keywords

  • Genetics
  • Insulin resistance
  • Lipidomics
  • Lipids
  • Obesity
  • Plasma lipidomics
  • Variance components

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Medicine(all)

Cite this

Kulkarni, H., Meikle, P. J., Mamtani, M., Weir, J. M., Almeida, M., Diego, V., ... Blangero, J. (2014). Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. Journal of Lipid Research, 55(5), 939-946. https://doi.org/10.1194/jlr.M044065

Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. / Kulkarni, Hemant; Meikle, Peter J.; Mamtani, Manju; Weir, Jacquelyn M.; Almeida, Marcio; Diego, Vincent; Peralta, Juan Manuel; Barlow, Christopher K.; Bellis, Claire; Dyer, Thomas D.; Almasy, Laura; Mahaney, Michael C.; Comuzzie, Anthony G.; Göring, Harald H H; Curran, Joanne E.; Blangero, John.

In: Journal of Lipid Research, Vol. 55, No. 5, 2014, p. 939-946.

Research output: Contribution to journalArticle

Kulkarni, H, Meikle, PJ, Mamtani, M, Weir, JM, Almeida, M, Diego, V, Peralta, JM, Barlow, CK, Bellis, C, Dyer, TD, Almasy, L, Mahaney, MC, Comuzzie, AG, Göring, HHH, Curran, JE & Blangero, J 2014, 'Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families', Journal of Lipid Research, vol. 55, no. 5, pp. 939-946. https://doi.org/10.1194/jlr.M044065
Kulkarni, Hemant ; Meikle, Peter J. ; Mamtani, Manju ; Weir, Jacquelyn M. ; Almeida, Marcio ; Diego, Vincent ; Peralta, Juan Manuel ; Barlow, Christopher K. ; Bellis, Claire ; Dyer, Thomas D. ; Almasy, Laura ; Mahaney, Michael C. ; Comuzzie, Anthony G. ; Göring, Harald H H ; Curran, Joanne E. ; Blangero, John. / Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. In: Journal of Lipid Research. 2014 ; Vol. 55, No. 5. pp. 939-946.
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