Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Hemant Kulkarni, Peter J. Meikle, Manju Mamtani, Jacquelyn M. Weir, Marcio Almeida, Vincent Diego, Juan Manuel Peralta, Christopher K. Barlow, Claire Bellis, Thomas D. Dyer, Laura Almasy, Michael C. Mahaney, Anthony G. Comuzzie, Harald H.H. Göring, Joanne E. Curran, John Blangero

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the highresolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic influences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22% of variability in the homeostatic model of assessment-insulin resistance trait and 16% to 22% variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in MS. - Kulkarni, H., P. J. Meikle, M. Mamtani, J. M. Weir, M. Almeida, V. Diego, J. M. Peralta, C. K. Barlow, C. Bellis, T. D. Dyer, L. Almasy, M. C. Mahaney, A. G. Comuzzie, H. H. H. Göring, J. E. Curran, and J. Blangero. Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. J. Lipid Res . 2014. 55: 939-946.

    Original languageEnglish (US)
    Pages (from-to)939-946
    Number of pages8
    JournalJournal of lipid research
    Volume55
    Issue number5
    DOIs
    StatePublished - May 2014

    Keywords

    • Genetics
    • Insulin resistance
    • Lipidomics
    • Lipids
    • Obesity
    • Plasma lipidomics
    • Variance components

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Cell Biology

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