Plasma levels of myokines and inflammatory markers are related with functional and respiratory performance in older adults with COPD and sarcopenia

Vanessa Kelly da Silva Lage, Fabiana Angélica de Paula, Liliana Pereira Lima, Joyce Noelly Vítor Santos, Jousielle Márcia dos Santos, Ângela Alves Viegas, Guilherme Pinto da Silva, Hellen Cristina de Almeida, Ana Luiza da Silva Nunes Teixeira Rodrigues, Amanda Aparecida Oliveira Leopoldino, Núbia Carelli Pereira de Avelar, Ana Lúcia Danielewicz, Adriana Netto Parentoni, Antônio Lúcio Teixeira, Murilo Xavier Oliveira, Ana Cristina Rodrigues Lacerda, Vanessa Amaral Mendonça

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This study investigated whether blood-based biomarkers were related to functional test performance and respiratory muscle strength in older adults with COPD and sarcopenia. The participants included in this cross-sectional study were from both sexes and sixty years or older. Based on clinical assessment, participants were categorized in COPD (n = 43) and non-COPD (NCOPD) (n = 43) groups. They were also assessed for body composition and muscular mass by dual-energy X-ray absorptiometry, using the relative skeletal muscle index for the diagnosis of sarcopenia. A series of functional tests, including short physical performance battery (SPPB), 6-minute walking test (6MWT), maximal inspiratory and expiratory pressures (MIP and MEP), were carried out. Plasma levels of myokines (Irisin and BDNF), and soluble TNF receptors (sTNFR1 and sTNFR2) were determined by ELISA. In the multivariate analysis, 6MWD was associated with age, COPD-related sarcopenia and BDNF (R2 = 0.29; f2 = 0.41). SPPB score was associated with COPD-related sarcopenia and sTNFR1 (R2 = 0.25; f2 = 0.33). MIP value was associated with sex, COPD-related sarcopenia, sTNFR2 and Irisin (R2 = 0.24; f2 = 0.31). Finally, MEP value was associated with sex COPD-related sarcopenia (R2 = 0.18; f2 = 0.22). Plasma levels of myokines and inflammatory markers are related with functional and respiratory performance in older adults with COPD and sarcopenia.

Original languageEnglish (US)
Article number111834
JournalExperimental Gerontology
Volume164
DOIs
StatePublished - Jul 2022
Externally publishedYes

Keywords

  • COPD
  • Myokines
  • Respiratory muscle strength and functional performance
  • Sarcopenia

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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