TY - JOUR
T1 - Plasma levels of myokines and inflammatory markers are related with functional and respiratory performance in older adults with COPD and sarcopenia
AU - Lage, Vanessa Kelly da Silva
AU - de Paula, Fabiana Angélica
AU - Lima, Liliana Pereira
AU - Santos, Joyce Noelly Vítor
AU - dos Santos, Jousielle Márcia
AU - Viegas, Ângela Alves
AU - da Silva, Guilherme Pinto
AU - de Almeida, Hellen Cristina
AU - Rodrigues, Ana Luiza da Silva Nunes Teixeira
AU - Leopoldino, Amanda Aparecida Oliveira
AU - de Avelar, Núbia Carelli Pereira
AU - Danielewicz, Ana Lúcia
AU - Parentoni, Adriana Netto
AU - Teixeira, Antônio Lúcio
AU - Oliveira, Murilo Xavier
AU - Lacerda, Ana Cristina Rodrigues
AU - Mendonça, Vanessa Amaral
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/7
Y1 - 2022/7
N2 - This study investigated whether blood-based biomarkers were related to functional test performance and respiratory muscle strength in older adults with COPD and sarcopenia. The participants included in this cross-sectional study were from both sexes and sixty years or older. Based on clinical assessment, participants were categorized in COPD (n = 43) and non-COPD (NCOPD) (n = 43) groups. They were also assessed for body composition and muscular mass by dual-energy X-ray absorptiometry, using the relative skeletal muscle index for the diagnosis of sarcopenia. A series of functional tests, including short physical performance battery (SPPB), 6-minute walking test (6MWT), maximal inspiratory and expiratory pressures (MIP and MEP), were carried out. Plasma levels of myokines (Irisin and BDNF), and soluble TNF receptors (sTNFR1 and sTNFR2) were determined by ELISA. In the multivariate analysis, 6MWD was associated with age, COPD-related sarcopenia and BDNF (R2 = 0.29; f2 = 0.41). SPPB score was associated with COPD-related sarcopenia and sTNFR1 (R2 = 0.25; f2 = 0.33). MIP value was associated with sex, COPD-related sarcopenia, sTNFR2 and Irisin (R2 = 0.24; f2 = 0.31). Finally, MEP value was associated with sex COPD-related sarcopenia (R2 = 0.18; f2 = 0.22). Plasma levels of myokines and inflammatory markers are related with functional and respiratory performance in older adults with COPD and sarcopenia.
AB - This study investigated whether blood-based biomarkers were related to functional test performance and respiratory muscle strength in older adults with COPD and sarcopenia. The participants included in this cross-sectional study were from both sexes and sixty years or older. Based on clinical assessment, participants were categorized in COPD (n = 43) and non-COPD (NCOPD) (n = 43) groups. They were also assessed for body composition and muscular mass by dual-energy X-ray absorptiometry, using the relative skeletal muscle index for the diagnosis of sarcopenia. A series of functional tests, including short physical performance battery (SPPB), 6-minute walking test (6MWT), maximal inspiratory and expiratory pressures (MIP and MEP), were carried out. Plasma levels of myokines (Irisin and BDNF), and soluble TNF receptors (sTNFR1 and sTNFR2) were determined by ELISA. In the multivariate analysis, 6MWD was associated with age, COPD-related sarcopenia and BDNF (R2 = 0.29; f2 = 0.41). SPPB score was associated with COPD-related sarcopenia and sTNFR1 (R2 = 0.25; f2 = 0.33). MIP value was associated with sex, COPD-related sarcopenia, sTNFR2 and Irisin (R2 = 0.24; f2 = 0.31). Finally, MEP value was associated with sex COPD-related sarcopenia (R2 = 0.18; f2 = 0.22). Plasma levels of myokines and inflammatory markers are related with functional and respiratory performance in older adults with COPD and sarcopenia.
KW - COPD
KW - Myokines
KW - Respiratory muscle strength and functional performance
KW - Sarcopenia
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U2 - 10.1016/j.exger.2022.111834
DO - 10.1016/j.exger.2022.111834
M3 - Article
C2 - 35588999
AN - SCOPUS:85130482122
SN - 0531-5565
VL - 164
JO - Experimental Gerontology
JF - Experimental Gerontology
M1 - 111834
ER -