TY - JOUR
T1 - Plasma levels of chemokines during leprosy specific treatment
AU - Mendonça, Vanessa Amaral
AU - Costa, Rosane Dias
AU - Lyon, Sandra
AU - Penido, Rachel Adriana
AU - Borges, Valdinéria Oliveira
AU - Bretas, Thales Lage
AU - Antunes, Carlos Mauricio
AU - Teixeira, Mauro Martins
AU - Teixeira, Antonio Lúcio
PY - 2010/2
Y1 - 2010/2
N2 - Leprosy, whose etiologic agent is Mycobacterium leprae, is an illness of ample clinical and immunopathological spectrum. Although chemokines seem to be involved in the immunopathogenesis of leprosis, few studies have been carried out to unveil the potential of chemokines as biological markers of the disease. The purpose of this study was to investigate the value of measuring CCL2, CCL3, CCL11 and CCL24 in plasma of patients with leprosy (LE) at different stages of multi-drug therapy (MDT). Chemokines were measured by ELISA in plasma of 30 non-infected individuals (NI) and 33 LE patients before and at different stages of treatment. The plasma concentration of CCL11 (p < 0.01) and CCL24 (p < 0.05) was increased in LE patients before treatment when compared to NI individuals. The plasma concentration of CCL24 decreased after MDT (p < 0.05). No differences were observed in the concentration of CCL2 and CCL3 in plasma of NI and LE individuals. The elevated levels of CCL11 and CCL24 in plasma of patients with LE suggest that these chemokines may play a role in disease pathogenesis. Moreover, the decrease of CCL24 after treatment suggests that this chemokine might be useful as a biomarker of response to MDT in patients with leprosy.
AB - Leprosy, whose etiologic agent is Mycobacterium leprae, is an illness of ample clinical and immunopathological spectrum. Although chemokines seem to be involved in the immunopathogenesis of leprosis, few studies have been carried out to unveil the potential of chemokines as biological markers of the disease. The purpose of this study was to investigate the value of measuring CCL2, CCL3, CCL11 and CCL24 in plasma of patients with leprosy (LE) at different stages of multi-drug therapy (MDT). Chemokines were measured by ELISA in plasma of 30 non-infected individuals (NI) and 33 LE patients before and at different stages of treatment. The plasma concentration of CCL11 (p < 0.01) and CCL24 (p < 0.05) was increased in LE patients before treatment when compared to NI individuals. The plasma concentration of CCL24 decreased after MDT (p < 0.05). No differences were observed in the concentration of CCL2 and CCL3 in plasma of NI and LE individuals. The elevated levels of CCL11 and CCL24 in plasma of patients with LE suggest that these chemokines may play a role in disease pathogenesis. Moreover, the decrease of CCL24 after treatment suggests that this chemokine might be useful as a biomarker of response to MDT in patients with leprosy.
KW - CCL11/eotaxin-1
KW - CCL24/eotaxin-2
KW - Chemokines
KW - Leprosy
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=74149085250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74149085250&partnerID=8YFLogxK
U2 - 10.1016/j.actatropica.2009.10.010
DO - 10.1016/j.actatropica.2009.10.010
M3 - Article
C2 - 19874796
AN - SCOPUS:74149085250
SN - 0001-706X
VL - 113
SP - 151
EP - 154
JO - Acta Tropica
JF - Acta Tropica
IS - 2
ER -