Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

Aline Mansueto Mourão, Laélia Cristina Caseiro Vicente, Mery Natali Silva Abreu, Romeu Vale Sant'Anna, Erica Leandro Marciano Vieira, Leonardo Cruz de Souza, Aline Silva de Miranda, Milene Alvarenga Rachid, Antônio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.

Original languageEnglish (US)
Pages (from-to)735-740
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume28
Issue number3
DOIs
StatePublished - Mar 2019
Externally publishedYes

Keywords

  • biomarker
  • Brain-derived neurotrophic factor
  • ichemic stroke
  • prognosis
  • stroke
  • stroke outcome

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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