Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

Aline Mansueto Mourão; Laélia Cristina Caseiro Vicente; Mery Natali Silva Abreu; Romeu Vale Sant'Anna; Erica Leandro Marciano Vieira; Leonardo Cruz de Souza; Aline Silva de Miranda; Milene Alvarenga Rachid; Antônio Lucio Teixeira

doi:10.1016/j.jstrokecerebrovasdis.2018.11.013

Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

Aline Mansueto Mourão, Laélia Cristina Caseiro Vicente, Mery Natali Silva Abreu, Romeu Vale Sant'Anna, Erica Leandro Marciano Vieira, Leonardo Cruz de Souza, Aline Silva de Miranda, Milene Alvarenga Rachid, Antônio Lucio Teixeira

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.

Original language	English (US)
Pages (from-to)	735-740
Number of pages	6
Journal	Journal of Stroke and Cerebrovascular Diseases
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.013
State	Published - Mar 2019
Externally published	Yes

Keywords

biomarker
Brain-derived neurotrophic factor
ichemic stroke
prognosis
stroke
stroke outcome

ASJC Scopus subject areas

Surgery
Rehabilitation
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1016/j.jstrokecerebrovasdis.2018.11.013

Cite this

Mourão, A. M., Vicente, L. C. C., Abreu, M. N. S., Vale Sant'Anna, R., Vieira, E. L. M., de Souza, L. C., de Miranda, A. S., Rachid, M. A., & Teixeira, A. L. (2019). Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases, 28(3), 735-740. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.013

Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke. / Mourão, Aline Mansueto; Vicente, Laélia Cristina Caseiro; Abreu, Mery Natali Silva et al.
In: Journal of Stroke and Cerebrovascular Diseases, Vol. 28, No. 3, 03.2019, p. 735-740.

Research output: Contribution to journal › Article › peer-review

Mourão, AM, Vicente, LCC, Abreu, MNS, Vale Sant'Anna, R, Vieira, ELM, de Souza, LC, de Miranda, AS, Rachid, MA & Teixeira, AL 2019, 'Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke', Journal of Stroke and Cerebrovascular Diseases, vol. 28, no. 3, pp. 735-740. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.013

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abstract = "Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.",

keywords = "biomarker, Brain-derived neurotrophic factor, ichemic stroke, prognosis, stroke, stroke outcome",

author = "Mour{\~a}o, {Aline Mansueto} and Vicente, {La{\'e}lia Cristina Caseiro} and Abreu, {Mery Natali Silva} and {Vale Sant'Anna}, Romeu and Vieira, {Erica Leandro Marciano} and {de Souza}, {Leonardo Cruz} and {de Miranda}, {Aline Silva} and Rachid, {Milene Alvarenga} and Teixeira, {Ant{\^o}nio Lucio}",

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doi = "10.1016/j.jstrokecerebrovasdis.2018.11.013",

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AU - Vicente, Laélia Cristina Caseiro

AU - Abreu, Mery Natali Silva

AU - Vale Sant'Anna, Romeu

AU - Vieira, Erica Leandro Marciano

AU - de Souza, Leonardo Cruz

AU - de Miranda, Aline Silva

AU - Rachid, Milene Alvarenga

AU - Teixeira, Antônio Lucio

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N2 - Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.

AB - Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.

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Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

Abstract

Keywords

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