Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis

H. H. Malluche, M. C. Faugere, P. Fanti, P. A. Price

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Abstract

Predictive value of plasma levels of bone Gla-protein (BGP) for bone histology was evaluated in 30 chronically dialyzed patients. All patients underwent bone biopsies and serum biochemical parameters, including BGP, parathyroid hormone, and alkaline phosphatase; calcium and phosphate were measured at the time of biopsy. Bone histology showed renal osteodystrophy with low bone turnover and osteomalacia (LT-ROD) in 13 patients, and renal osteodystrophy with high bone turnover and prevailing hyperparathyroid bone disease (HT-ROD) in 17 patients. Values for BGP were above normal in LT-ROD (47.3 ± 7.9 vs. 6.8 ± 0.2 ng/ml) and extremely elevated in HT-ROD (831 ± 170 ng/ml). Similar differences were not found with the other serum biochemical parameters, even though BGP correlated with parathyroid hormone (r = 0.64) and alkaline phosphatase (r = 0.85). There were significant correlations between BGP and cellular and non-cellular parameters of bone formation (r = 0.73 to 0.91). Weaker or no correlations were found between BGP and histologic parameters of bone, reflecting mainly mineralization or resorption. These correlations and the finding of significant differences in plasma BGP beteen LT-ROD and HT-ROD indicate that plasma levels of BGP reflect bone formation in uremia and predict underlying bone histology.

Original languageEnglish (US)
Pages (from-to)869-874
Number of pages6
JournalKidney International
Volume26
Issue number6
StatePublished - 1984
Externally publishedYes

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Osteocalcin
Osteogenesis
Dialysis
Maintenance
Bone Diseases
Bone and Bones
Chronic Kidney Disease-Mineral and Bone Disorder
Histology
Bone Remodeling
Parathyroid Hormone
Alkaline Phosphatase
Biopsy
Osteomalacia
Uremia
Serum
Blood Proteins

ASJC Scopus subject areas

  • Nephrology

Cite this

Malluche, H. H., Faugere, M. C., Fanti, P., & Price, P. A. (1984). Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis. Kidney International, 26(6), 869-874.

Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis. / Malluche, H. H.; Faugere, M. C.; Fanti, P.; Price, P. A.

In: Kidney International, Vol. 26, No. 6, 1984, p. 869-874.

Research output: Contribution to journalArticle

Malluche, HH, Faugere, MC, Fanti, P & Price, PA 1984, 'Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis', Kidney International, vol. 26, no. 6, pp. 869-874.
Malluche, H. H. ; Faugere, M. C. ; Fanti, P. ; Price, P. A. / Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis. In: Kidney International. 1984 ; Vol. 26, No. 6. pp. 869-874.
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