Plasma levels of alarmin IL-33 are unchanged in autism spectrum disorder: A preliminary study

Izabela Guimarães Barbosa, David Henrique Rodrigues, Natália Pessoa Rocha, Larissa Fonseca da Cunha Sousa, Erica Leandro M. Vieira, Ana Cristina Simões-e-Silva, Arthur Kummer, AntÔnio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The pathogenesis of autism spectrum disorder (ASD) is unknown, and the immune system has been appointed to play an important role. The interleukin 33 (IL-33), a member of the IL-1, may act as an alarmin. This study aimed to evaluate plasma levels of IL-33, sST2, and IL-1β in 30 patients with ASD in comparison with 18 controls matched by gender, age and maternal age at childbirth. Patients did not differ from controls in IL-33, sST2, and IL-1β plasma levels. Alarmin levels were not correlated with age, and neither was influenced by clinical parameters. Our results undermine the role of IL-33/ST2 in ASD.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalJournal of Neuroimmunology
Volume278
DOIs
StatePublished - Jan 15 2015
Externally publishedYes

Keywords

  • Autism
  • Cytokines
  • IL-1β
  • IL-33
  • SST2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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