TY - JOUR
T1 - Plasma levels of alarmin IL-33 are unchanged in autism spectrum disorder
T2 - A preliminary study
AU - Barbosa, Izabela Guimarães
AU - Rodrigues, David Henrique
AU - Rocha, Natália Pessoa
AU - Sousa, Larissa Fonseca da Cunha
AU - Vieira, Erica Leandro M.
AU - Simões-e-Silva, Ana Cristina
AU - Kummer, Arthur
AU - Teixeira, AntÔnio Lúcio
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - The pathogenesis of autism spectrum disorder (ASD) is unknown, and the immune system has been appointed to play an important role. The interleukin 33 (IL-33), a member of the IL-1, may act as an alarmin. This study aimed to evaluate plasma levels of IL-33, sST2, and IL-1β in 30 patients with ASD in comparison with 18 controls matched by gender, age and maternal age at childbirth. Patients did not differ from controls in IL-33, sST2, and IL-1β plasma levels. Alarmin levels were not correlated with age, and neither was influenced by clinical parameters. Our results undermine the role of IL-33/ST2 in ASD.
AB - The pathogenesis of autism spectrum disorder (ASD) is unknown, and the immune system has been appointed to play an important role. The interleukin 33 (IL-33), a member of the IL-1, may act as an alarmin. This study aimed to evaluate plasma levels of IL-33, sST2, and IL-1β in 30 patients with ASD in comparison with 18 controls matched by gender, age and maternal age at childbirth. Patients did not differ from controls in IL-33, sST2, and IL-1β plasma levels. Alarmin levels were not correlated with age, and neither was influenced by clinical parameters. Our results undermine the role of IL-33/ST2 in ASD.
KW - Autism
KW - Cytokines
KW - IL-1β
KW - IL-33
KW - SST2
UR - http://www.scopus.com/inward/record.url?scp=84920911230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920911230&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2014.11.021
DO - 10.1016/j.jneuroim.2014.11.021
M3 - Article
C2 - 25595254
AN - SCOPUS:84920911230
SN - 0165-5728
VL - 278
SP - 69
EP - 72
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -