Plasma glucose and the action of calorie restriction on aging

Roger McCarter, Walter Mejia, Yuji Ikeno, Vincent Monnier, Kristen Kewitt, Michael Gibbs, Alex McMahan, John R Strong

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6 mice expressing a human GLUT4 minigene (transgenic [TG] mice) and their nontransgenic littermates (NTG mice) were maintained under specific pathogen-free conditions. Mice were fed ad libitum (A mice) or 40% less than ad libitum (R mice) from age 6 weeks. Over the life span there were three different levels of plasma glucose, with NTGA mice having the highest daily levels, TGR mice the lowest daily values, and TGA and NTGR mice having similar levels intermediate between these values. Despite differences in plasma glucose, the differences measured in longevity (50% and 10% survival), physiology and tissue pathology were associated with diet rather than with levels of plasma glucose. We conclude that decreased plasma glucose over the life span is not an important factor in the action of calorie restriction on aging processes.

Original languageEnglish (US)
Pages (from-to)1059-1070
Number of pages12
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume62
Issue number10
StatePublished - Oct 2007

Fingerprint

Glucose
Specific Pathogen-Free Organisms
Tissue Survival
Caloric Restriction
Inbred C57BL Mouse
Transgenic Mice
Pathology
Diet

ASJC Scopus subject areas

  • Aging

Cite this

Plasma glucose and the action of calorie restriction on aging. / McCarter, Roger; Mejia, Walter; Ikeno, Yuji; Monnier, Vincent; Kewitt, Kristen; Gibbs, Michael; McMahan, Alex; Strong, John R.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 10, 10.2007, p. 1059-1070.

Research output: Contribution to journalArticle

McCarter, R, Mejia, W, Ikeno, Y, Monnier, V, Kewitt, K, Gibbs, M, McMahan, A & Strong, JR 2007, 'Plasma glucose and the action of calorie restriction on aging', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 62, no. 10, pp. 1059-1070.
McCarter, Roger ; Mejia, Walter ; Ikeno, Yuji ; Monnier, Vincent ; Kewitt, Kristen ; Gibbs, Michael ; McMahan, Alex ; Strong, John R. / Plasma glucose and the action of calorie restriction on aging. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2007 ; Vol. 62, No. 10. pp. 1059-1070.
@article{edeec078e791483098f87e6056ec8837,
title = "Plasma glucose and the action of calorie restriction on aging",
abstract = "We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6 mice expressing a human GLUT4 minigene (transgenic [TG] mice) and their nontransgenic littermates (NTG mice) were maintained under specific pathogen-free conditions. Mice were fed ad libitum (A mice) or 40{\%} less than ad libitum (R mice) from age 6 weeks. Over the life span there were three different levels of plasma glucose, with NTGA mice having the highest daily levels, TGR mice the lowest daily values, and TGA and NTGR mice having similar levels intermediate between these values. Despite differences in plasma glucose, the differences measured in longevity (50{\%} and 10{\%} survival), physiology and tissue pathology were associated with diet rather than with levels of plasma glucose. We conclude that decreased plasma glucose over the life span is not an important factor in the action of calorie restriction on aging processes.",
author = "Roger McCarter and Walter Mejia and Yuji Ikeno and Vincent Monnier and Kristen Kewitt and Michael Gibbs and Alex McMahan and Strong, {John R}",
year = "2007",
month = "10",
language = "English (US)",
volume = "62",
pages = "1059--1070",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Plasma glucose and the action of calorie restriction on aging

AU - McCarter, Roger

AU - Mejia, Walter

AU - Ikeno, Yuji

AU - Monnier, Vincent

AU - Kewitt, Kristen

AU - Gibbs, Michael

AU - McMahan, Alex

AU - Strong, John R

PY - 2007/10

Y1 - 2007/10

N2 - We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6 mice expressing a human GLUT4 minigene (transgenic [TG] mice) and their nontransgenic littermates (NTG mice) were maintained under specific pathogen-free conditions. Mice were fed ad libitum (A mice) or 40% less than ad libitum (R mice) from age 6 weeks. Over the life span there were three different levels of plasma glucose, with NTGA mice having the highest daily levels, TGR mice the lowest daily values, and TGA and NTGR mice having similar levels intermediate between these values. Despite differences in plasma glucose, the differences measured in longevity (50% and 10% survival), physiology and tissue pathology were associated with diet rather than with levels of plasma glucose. We conclude that decreased plasma glucose over the life span is not an important factor in the action of calorie restriction on aging processes.

AB - We tested the hypothesis that retardation of aging by caloric restriction is due in part to decreased levels of plasma glucose over the life span. Male C57BL/6 mice expressing a human GLUT4 minigene (transgenic [TG] mice) and their nontransgenic littermates (NTG mice) were maintained under specific pathogen-free conditions. Mice were fed ad libitum (A mice) or 40% less than ad libitum (R mice) from age 6 weeks. Over the life span there were three different levels of plasma glucose, with NTGA mice having the highest daily levels, TGR mice the lowest daily values, and TGA and NTGR mice having similar levels intermediate between these values. Despite differences in plasma glucose, the differences measured in longevity (50% and 10% survival), physiology and tissue pathology were associated with diet rather than with levels of plasma glucose. We conclude that decreased plasma glucose over the life span is not an important factor in the action of calorie restriction on aging processes.

UR - http://www.scopus.com/inward/record.url?scp=35349008023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35349008023&partnerID=8YFLogxK

M3 - Article

C2 - 17921417

AN - SCOPUS:35349008023

VL - 62

SP - 1059

EP - 1070

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 10

ER -