Plasma GABA predicts acute response to divalproex in mania

Frederick Petty; A. John Rush; John M. Davis; Joseph R. Calabrese; Susan E. Kimmel; Gerald L. Kramer; Joyce G. Small; Marvin J. Miller; Alan E. Swann; Paul J. Orsulak; Molly E. Blake; Charles L. Bowden

doi:10.1016/0006-3223(95)00141-7

Plasma GABA predicts acute response to divalproex in mania

Frederick Petty, A. John Rush, John M. Davis, Joseph R. Calabrese, Susan E. Kimmel, Gerald L. Kramer, Joyce G. Small, Marvin J. Miller, Alan E. Swann, Paul J. Orsulak, Molly E. Blake, Charles L. Bowden

Psychiatry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial, Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p <.05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.

Original language	English (US)
Pages (from-to)	278-284
Number of pages	7
Journal	Biological Psychiatry
Volume	39
Issue number	4
DOIs	https://doi.org/10.1016/0006-3223(95)00141-7
State	Published - Feb 15 1996

Keywords

Bipolar disorder
Divalproex
GABA
Lithium
Mania
Response prediction
Valproic acid

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(95)00141-7

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@article{585bf749ef114e61a306b1223f20b209,

title = "Plasma GABA predicts acute response to divalproex in mania",

abstract = "Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial, Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p <.05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.",

keywords = "Bipolar disorder, Divalproex, GABA, Lithium, Mania, Response prediction, Valproic acid",

author = "Frederick Petty and Rush, {A. John} and Davis, {John M.} and Calabrese, {Joseph R.} and Kimmel, {Susan E.} and Kramer, {Gerald L.} and Small, {Joyce G.} and Miller, {Marvin J.} and Swann, {Alan E.} and Orsulak, {Paul J.} and Blake, {Molly E.} and Bowden, {Charles L.}",

note = "Funding Information: This study was supported by the Department of Veterans Affairs Medical Research Service, NIH Research Grants MH37899 and MH41115, Abbott Laboratories, and the John Schermerhorn Fund.",

year = "1996",

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doi = "10.1016/0006-3223(95)00141-7",

language = "English (US)",

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T1 - Plasma GABA predicts acute response to divalproex in mania

AU - Petty, Frederick

AU - Rush, A. John

AU - Davis, John M.

AU - Calabrese, Joseph R.

AU - Kimmel, Susan E.

AU - Kramer, Gerald L.

AU - Small, Joyce G.

AU - Miller, Marvin J.

AU - Swann, Alan E.

AU - Orsulak, Paul J.

AU - Blake, Molly E.

AU - Bowden, Charles L.

N1 - Funding Information: This study was supported by the Department of Veterans Affairs Medical Research Service, NIH Research Grants MH37899 and MH41115, Abbott Laboratories, and the John Schermerhorn Fund.

PY - 1996/2/15

Y1 - 1996/2/15

N2 - Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial, Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p <.05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.

AB - Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial, Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p <.05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.

KW - Bipolar disorder

KW - Divalproex

KW - GABA

KW - Lithium

KW - Mania

KW - Response prediction

KW - Valproic acid

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Plasma GABA predicts acute response to divalproex in mania

Abstract

Keywords

ASJC Scopus subject areas

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