Plasma dihydroceramide species associate with waist circumference in Mexican American families

Manju Mamtani, Peter J. Meikle, Hemant Kulkarni, Jacquelyn M. Weir, Christopher K. Barlow, Jeremy B. Jowett, Claire Bellis, Thomas D. Dyer, Laura Almasy, Michael C. Mahaney, Ravindranath Duggirala, Anthony G. Comuzzie, John Blangero, Joanne E. Curran

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.

Original languageEnglish (US)
Pages (from-to)950-956
Number of pages7
JournalObesity
Volume22
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Waist Circumference
Type 2 Diabetes Mellitus
Lipids
dihydroceramide
Sphingomyelins
Abdominal Obesity
Liquid Chromatography
HDL Cholesterol
Insulin Resistance
Mass Spectrometry
Triglycerides
Body Mass Index
Homeostasis
Software
Biomarkers

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Mamtani, M., Meikle, P. J., Kulkarni, H., Weir, J. M., Barlow, C. K., Jowett, J. B., ... Curran, J. E. (2014). Plasma dihydroceramide species associate with waist circumference in Mexican American families. Obesity, 22(3), 950-956. https://doi.org/10.1002/oby.20598

Plasma dihydroceramide species associate with waist circumference in Mexican American families. / Mamtani, Manju; Meikle, Peter J.; Kulkarni, Hemant; Weir, Jacquelyn M.; Barlow, Christopher K.; Jowett, Jeremy B.; Bellis, Claire; Dyer, Thomas D.; Almasy, Laura; Mahaney, Michael C.; Duggirala, Ravindranath; Comuzzie, Anthony G.; Blangero, John; Curran, Joanne E.

In: Obesity, Vol. 22, No. 3, 2014, p. 950-956.

Research output: Contribution to journalArticle

Mamtani, M, Meikle, PJ, Kulkarni, H, Weir, JM, Barlow, CK, Jowett, JB, Bellis, C, Dyer, TD, Almasy, L, Mahaney, MC, Duggirala, R, Comuzzie, AG, Blangero, J & Curran, JE 2014, 'Plasma dihydroceramide species associate with waist circumference in Mexican American families', Obesity, vol. 22, no. 3, pp. 950-956. https://doi.org/10.1002/oby.20598
Mamtani M, Meikle PJ, Kulkarni H, Weir JM, Barlow CK, Jowett JB et al. Plasma dihydroceramide species associate with waist circumference in Mexican American families. Obesity. 2014;22(3):950-956. https://doi.org/10.1002/oby.20598
Mamtani, Manju ; Meikle, Peter J. ; Kulkarni, Hemant ; Weir, Jacquelyn M. ; Barlow, Christopher K. ; Jowett, Jeremy B. ; Bellis, Claire ; Dyer, Thomas D. ; Almasy, Laura ; Mahaney, Michael C. ; Duggirala, Ravindranath ; Comuzzie, Anthony G. ; Blangero, John ; Curran, Joanne E. / Plasma dihydroceramide species associate with waist circumference in Mexican American families. In: Obesity. 2014 ; Vol. 22, No. 3. pp. 950-956.
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abstract = "Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.",
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