Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume

Shraddha Sapkota; Kelsey Erickson; Danielle Harvey; Sarah E. Tomaszewski-Farias; John M. Olichney; David K. Johnson; Brittany N. Dugger; Dan M. Mungas; Evan Fletcher; Pauline Maillard; Sudha Seshadri; Claudia L. Satizabal; Tiffany Kautz; Danielle Parent; Russell P. Tracy; Izumi Maezawa; Lee Way Jin; Charles DeCarli

doi:10.1002/dad2.12349

Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume

Shraddha Sapkota, Kelsey Erickson, Danielle Harvey, Sarah E. Tomaszewski-Farias, John M. Olichney, David K. Johnson, Brittany N. Dugger, Dan M. Mungas, Evan Fletcher, Pauline Maillard, Sudha Seshadri, Claudia L. Satizabal, Tiffany Kautz, Danielle Parent, Russell P. Tracy, Izumi Maezawa, Lee Way Jin, Charles DeCarli

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods: All participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center (n = 473; baseline age range = 49—95 years, 60% women). We applied an accelerated longitudinal design to test latent growth models for EF and EM, and path and mediation analyses. Age was centered at 75 years, and all models were adjusted for sex, education, and ethnicity. Results: HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance. Discussion: Neurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample.

Original language	English (US)
Article number	e12349
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12349
State	Published - 2022

Keywords

Alzheimer's disease
amyloid β 42/40
cognition
hippocampal volume
neurofilament light
plasma biomarkers
total-tau

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

Access to Document

10.1002/dad2.12349

Cite this

Sapkota, S., Erickson, K., Harvey, D., Tomaszewski-Farias, S. E., Olichney, J. M., Johnson, D. K., Dugger, B. N., Mungas, D. M., Fletcher, E., Maillard, P., Seshadri, S., Satizabal, C. L., Kautz, T., Parent, D., Tracy, R. P., Maezawa, I., Jin, L. W., & DeCarli, C. (2022). Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), Article e12349. https://doi.org/10.1002/dad2.12349

Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume. / Sapkota, Shraddha; Erickson, Kelsey; Harvey, Danielle et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 14, No. 1, e12349, 2022.

Research output: Contribution to journal › Article › peer-review

Sapkota, S, Erickson, K, Harvey, D, Tomaszewski-Farias, SE, Olichney, JM, Johnson, DK, Dugger, BN, Mungas, DM, Fletcher, E, Maillard, P, Seshadri, S , Satizabal, CL , Kautz, T, Parent, D, Tracy, RP, Maezawa, I, Jin, LW & DeCarli, C 2022, 'Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 14, no. 1, e12349. https://doi.org/10.1002/dad2.12349

@article{62abd26adc464279be6d67968fa0b0b5,

title = "Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume",

abstract = "Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods: All participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center (n = 473; baseline age range = 49—95 years, 60% women). We applied an accelerated longitudinal design to test latent growth models for EF and EM, and path and mediation analyses. Age was centered at 75 years, and all models were adjusted for sex, education, and ethnicity. Results: HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance. Discussion: Neurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample.",

keywords = "Alzheimer's disease, amyloid β 42/40, cognition, hippocampal volume, neurofilament light, plasma biomarkers, total-tau",

author = "Shraddha Sapkota and Kelsey Erickson and Danielle Harvey and Tomaszewski-Farias, {Sarah E.} and Olichney, {John M.} and Johnson, {David K.} and Dugger, {Brittany N.} and Mungas, {Dan M.} and Evan Fletcher and Pauline Maillard and Sudha Seshadri and Satizabal, {Claudia L.} and Tiffany Kautz and Danielle Parent and Tracy, {Russell P.} and Izumi Maezawa and Jin, {Lee Way} and Charles DeCarli",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

year = "2022",

doi = "10.1002/dad2.12349",

language = "English (US)",

volume = "14",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort

T2 - Mediation with hippocampal volume

AU - Sapkota, Shraddha

AU - Erickson, Kelsey

AU - Harvey, Danielle

AU - Tomaszewski-Farias, Sarah E.

AU - Olichney, John M.

AU - Johnson, David K.

AU - Dugger, Brittany N.

AU - Mungas, Dan M.

AU - Fletcher, Evan

AU - Maillard, Pauline

AU - Seshadri, Sudha

AU - Satizabal, Claudia L.

AU - Kautz, Tiffany

AU - Parent, Danielle

AU - Tracy, Russell P.

AU - Maezawa, Izumi

AU - Jin, Lee Way

AU - DeCarli, Charles

PY - 2022

Y1 - 2022

N2 - Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods: All participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center (n = 473; baseline age range = 49—95 years, 60% women). We applied an accelerated longitudinal design to test latent growth models for EF and EM, and path and mediation analyses. Age was centered at 75 years, and all models were adjusted for sex, education, and ethnicity. Results: HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance. Discussion: Neurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample.

AB - Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods: All participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center (n = 473; baseline age range = 49—95 years, 60% women). We applied an accelerated longitudinal design to test latent growth models for EF and EM, and path and mediation analyses. Age was centered at 75 years, and all models were adjusted for sex, education, and ethnicity. Results: HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance. Discussion: Neurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample.

KW - Alzheimer's disease

KW - amyloid β 42/40

KW - cognition

KW - hippocampal volume

KW - neurofilament light

KW - plasma biomarkers

KW - total-tau

UR - http://www.scopus.com/inward/record.url?scp=85145039005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85145039005&partnerID=8YFLogxK

U2 - 10.1002/dad2.12349

DO - 10.1002/dad2.12349

M3 - Article

C2 - 36092690

AN - SCOPUS:85145039005

SN - 2352-8729

VL - 14

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

M1 - e12349

ER -

Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this