Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume

Shraddha Sapkota, Kelsey Erickson, Danielle Harvey, Sarah E. Tomaszewski-Farias, John M. Olichney, David K. Johnson, Brittany N. Dugger, Dan M. Mungas, Evan Fletcher, Pauline Maillard, Sudha Seshadri, Claudia L. Satizabal, Tiffany Kautz, Danielle Parent, Russell P. Tracy, Izumi Maezawa, Lee Way Jin, Charles DeCarli

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods: All participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center (n = 473; baseline age range = 49—95 years, 60% women). We applied an accelerated longitudinal design to test latent growth models for EF and EM, and path and mediation analyses. Age was centered at 75 years, and all models were adjusted for sex, education, and ethnicity. Results: HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance. Discussion: Neurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample.

Original languageEnglish (US)
Article numbere12349
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume14
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Alzheimer's disease
  • amyloid β 42/40
  • cognition
  • hippocampal volume
  • neurofilament light
  • plasma biomarkers
  • total-tau

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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