Abstract
Background: Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Patients and Methods: Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with nonsmall cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. Results: When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94.
Original language | English (US) |
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Pages (from-to) | 27-35 |
Number of pages | 9 |
Journal | Cancer Genomics and Proteomics |
Volume | 9 |
Issue number | 1 |
State | Published - 2012 |
Keywords
- Asthma
- Autoantibodies
- Biomarker
- Multiplex assay
- Non-small cell lung cancer
- Plasma
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics
- Cancer Research