Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women

Elzbieta Izbicka, Robert T. Streeper, Joel E. Michalek, Christopher L. Louden, Armando Diaz, David R. Campos

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Patients and Methods: Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with nonsmall cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. Results: When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalCancer Genomics and Proteomics
Volume9
Issue number1
StatePublished - Jan 1 2012

Keywords

  • Asthma
  • Autoantibodies
  • Biomarker
  • Multiplex assay
  • Non-small cell lung cancer
  • Plasma

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cancer Research

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