Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women

Elzbieta Izbicka; Robert T. Streeper; Joel E. Michalek; Christopher L. Louden; Armando Diaz; David R. Campos

Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women

Elzbieta Izbicka, Robert T. Streeper, Joel E. Michalek, Christopher L. Louden, Armando Diaz, David R. Campos

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Patients and Methods: Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with nonsmall cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. Results: When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94.

Original language	English (US)
Pages (from-to)	27-35
Number of pages	9
Journal	Cancer Genomics and Proteomics
Volume	9
Issue number	1
State	Published - 2012

Keywords

Asthma
Autoantibodies
Biomarker
Multiplex assay
Non-small cell lung cancer
Plasma

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Cancer Research

Cite this

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abstract = "Background: Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Patients and Methods: Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with nonsmall cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. Results: When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94.",

keywords = "Asthma, Autoantibodies, Biomarker, Multiplex assay, Non-small cell lung cancer, Plasma",

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journal = "Cancer Genomics and Proteomics",

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T1 - Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women

AU - Izbicka, Elzbieta

AU - Streeper, Robert T.

AU - Michalek, Joel E.

AU - Louden, Christopher L.

AU - Diaz, Armando

AU - Campos, David R.

PY - 2012

Y1 - 2012

N2 - Background: Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Patients and Methods: Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with nonsmall cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. Results: When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94.

AB - Background: Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Patients and Methods: Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with nonsmall cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. Results: When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94.

KW - Asthma

KW - Autoantibodies

KW - Biomarker

KW - Multiplex assay

KW - Non-small cell lung cancer

KW - Plasma

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Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women

Abstract

Keywords

ASJC Scopus subject areas

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