Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women

Elzbieta Izbicka, Robert T. Streeper, Joel E. Michalek, Christopher L. Louden, Armando Diaz, David R. Campos

    Research output: Contribution to journalArticlepeer-review

    31 Scopus citations

    Abstract

    Background: Lung cancer (LC) is the leading cause of deaths caused by cancer worldwide. A diagnostic test for LC is needed for monitoring high-risk populations. Patients and Methods: Fifty-seven markers were measured using multiplex immunoassays of plasma of patients with nonsmall cell lung cancer (NSCLC); (245 men, 114 women, 1 unknown), asthma (67 men, 111 women, 2 unknown) and of healthy controls (165 men, 122 women, 1 unknown). Mass spectrometry was used for biomarker discovery. A support vector machine (SVM) was used for data analysis. Results: When all biomarkers and both genders were co-analyzed, SVM classified NSCLC and asthma with an accuracy of 0.94.

    Original languageEnglish (US)
    Pages (from-to)27-35
    Number of pages9
    JournalCancer Genomics and Proteomics
    Volume9
    Issue number1
    StatePublished - 2012

    Keywords

    • Asthma
    • Autoantibodies
    • Biomarker
    • Multiplex assay
    • Non-small cell lung cancer
    • Plasma

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Genetics
    • Cancer Research

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