Plasma binding of chlordiazepoxide, diazepam, lorazepam, and oxazepam was determined by equilibrium dialysis in 20 male, healthy volunteers, 25‐86 years old. A wide range of binding was observed, with the free fraction varying twofold for lorazepam, fourfold for chlordiazepoxide and diazepam, and over 20‐fold for oxazepam. Statistically significant linear relationships were not observed between the degree of binding and age, serum albumin, or total protein for any of the drugs. There was, however, a correlation between the extent of binding for the four drugs. Because of the importance of unbound benzodiazepine levels in eliciting any pharmacological response and also in disposition, consideration of the wide interindividual variability in plasma binding must be made in interpreting pharmacodynamic and pharmacokinetic data.
- Benzodiazepines—plasma binding, equilibrium diaiysis, humans, individual variation, age
- Plasma binding—benzodiazepines, humans, individual variation, age
- Sedatives—benzodiazepines, plasma binding, equilibrium dialysis, humans, individual variation, age
ASJC Scopus subject areas
- Pharmaceutical Science