Plasma and erythrocyte electrolytes in affective disorders

Alan Frazer, T. Alan Ramsey, Alan Swann, Charles Bowden, David Brunswick, David Garver, Steven Secunda

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Plasma and erythrocyte sodium (Na+), total and free (ultrafiltrable) plasma magnesium (Mg2+) as well as erythrocyte magnesium were measured in patients with affective disorders and in healthy control subjects. Depressed and manic patients had higher total plasma Mg2+ than did hospitalized healthy control subjects, but concentrations of ultrafiltrable Mg2+ did not differ. Although erythrocyte Mg2+ was significantly elevated in the depressed subjects in comparison with that found in the non-hospitalized healthy controls, this difference was not seen between the depressives and the hospitalized healthy controls. Depressed, manic or healthy control subjects did not differ with respect to either plasma or erythrocyte Na+ concentrations. These studies do not demonstrate any physiologically important abnormality of Mg2+ or Na+ metabolism in depressed or manic patients.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalJournal of Affective Disorders
Issue number2
StatePublished - May 1983

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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