PLAB, a novel placental bone morphogenetic protein

Robert Hromas, Matthew Hufford, Jill Sutton, Dawei Xu, Yunxing Li, Li Lu

Research output: Contribution to journalArticlepeer-review

161 Scopus citations

Abstract

Bone morphogenetic proteins (BMP) constitute a sub-group of the large transforming growth factor-beta (TGF-β) family. They play important roles in the embryonic development of multiple structures and in adult bone modeling. We have recently isolated a novel member of the BMP family from placenta, termed PLAB. PLAB is expressed highly in placenta, but can be found upon stringent analysis in low levels in most other tissues. At the amino acid level, PLAB is most closely related to BMP-8/OP-2, another member of the BMP family. Like TGF-β, PLAB inhibits the proliferation of primitive hematopoietic progenitors. The high expression of PLAB by placenta raises the possibility that it may be a mediator of placental control of embryonic development.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1354
Issue number1
DOIs
StatePublished - Oct 1 1997
Externally publishedYes

Keywords

  • Bone morphogenetic protein
  • Embryonic development
  • Placenta

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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