Pithomyces species (Montagnulaceae) from clinical specimens: Identification and antifungal susceptibility profiles

Keith Cássia Da Cunha; Deanna A. Sutton; Josepa Gené; Josep Cano; Javier Capilla; Hugo Madrid; Cony Decock; Nathan P. Wiederhold; Josep Guarro

doi:10.1093/mmy/myu044

Pithomyces species (Montagnulaceae) from clinical specimens: Identification and antifungal susceptibility profiles

Keith Cássia Da Cunha, Deanna A. Sutton, Josepa Gené, Josep Cano, Javier Capilla, Hugo Madrid, Cony Decock, Nathan P. Wiederhold, Josep Guarro

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The fungal genus Pithomyces comprises numerous dematiaceous saprobic species commonly found on dead leaves and stems of a great variety of plants. Occasionally, they have been recovered from clinical specimens. We morphologically and molecularly (rDNA sequences) investigated a set of 42 isolates tentatively identified as Pithomyces recovered from clinical specimens in the United States. The predominant species were P. chartarum and P. sacchari (33.3% each), followed by Pithomyces sp. I (28.6%) and P. maydicus (4.8%). Most of the isolates were obtained from samples of superficial tissue (50%), the respiratory tract (21.4%), and the nasal region (19%). In general, these fungi were highly susceptible in vitro to the eight antifungal agents tested.

Original language	English (US)
Pages (from-to)	748-757
Number of pages	10
Journal	Medical mycology
Volume	52
Issue number	7
DOIs	https://doi.org/10.1093/mmy/myu044
State	Published - Jul 22 2014

Keywords

DNA analysis
Pithomyces
antifungal susceptibility
clinical specimens
morphological identification

ASJC Scopus subject areas

Infectious Diseases

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10.1093/mmy/myu044

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title = "Pithomyces species (Montagnulaceae) from clinical specimens: Identification and antifungal susceptibility profiles",

abstract = "The fungal genus Pithomyces comprises numerous dematiaceous saprobic species commonly found on dead leaves and stems of a great variety of plants. Occasionally, they have been recovered from clinical specimens. We morphologically and molecularly (rDNA sequences) investigated a set of 42 isolates tentatively identified as Pithomyces recovered from clinical specimens in the United States. The predominant species were P. chartarum and P. sacchari (33.3\% each), followed by Pithomyces sp. I (28.6\%) and P. maydicus (4.8\%). Most of the isolates were obtained from samples of superficial tissue (50\%), the respiratory tract (21.4\%), and the nasal region (19\%). In general, these fungi were highly susceptible in vitro to the eight antifungal agents tested.",

keywords = "DNA analysis, Pithomyces, antifungal susceptibility, clinical specimens, morphological identification",

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doi = "10.1093/mmy/myu044",

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T1 - Pithomyces species (Montagnulaceae) from clinical specimens

T2 - Identification and antifungal susceptibility profiles

AU - Da Cunha, Keith Cássia

AU - Sutton, Deanna A.

AU - Gené, Josepa

AU - Cano, Josep

AU - Capilla, Javier

AU - Madrid, Hugo

AU - Decock, Cony

AU - Wiederhold, Nathan P.

AU - Guarro, Josep

PY - 2014/7/22

Y1 - 2014/7/22

N2 - The fungal genus Pithomyces comprises numerous dematiaceous saprobic species commonly found on dead leaves and stems of a great variety of plants. Occasionally, they have been recovered from clinical specimens. We morphologically and molecularly (rDNA sequences) investigated a set of 42 isolates tentatively identified as Pithomyces recovered from clinical specimens in the United States. The predominant species were P. chartarum and P. sacchari (33.3% each), followed by Pithomyces sp. I (28.6%) and P. maydicus (4.8%). Most of the isolates were obtained from samples of superficial tissue (50%), the respiratory tract (21.4%), and the nasal region (19%). In general, these fungi were highly susceptible in vitro to the eight antifungal agents tested.

AB - The fungal genus Pithomyces comprises numerous dematiaceous saprobic species commonly found on dead leaves and stems of a great variety of plants. Occasionally, they have been recovered from clinical specimens. We morphologically and molecularly (rDNA sequences) investigated a set of 42 isolates tentatively identified as Pithomyces recovered from clinical specimens in the United States. The predominant species were P. chartarum and P. sacchari (33.3% each), followed by Pithomyces sp. I (28.6%) and P. maydicus (4.8%). Most of the isolates were obtained from samples of superficial tissue (50%), the respiratory tract (21.4%), and the nasal region (19%). In general, these fungi were highly susceptible in vitro to the eight antifungal agents tested.

KW - DNA analysis

KW - Pithomyces

KW - antifungal susceptibility

KW - clinical specimens

KW - morphological identification

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IS - 7

ER -

Pithomyces species (Montagnulaceae) from clinical specimens: Identification and antifungal susceptibility profiles

Abstract

Keywords

ASJC Scopus subject areas

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