Pipradrol conditioned place preference is blocked by SCH23390

Norman M. White, Noboru Hiroi

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We investigated the effect of the selective D1 dopamine antagonist, SCH23390, on the establishment of a pipradrol-conditioned place preference (CPP). Among various doses of pipradrol (6.25-75.0 mg/kg, SC), a CPP was established at 25.0 mg/kg. SCH23390 (0.16 mg/kg, IP) blocked establishment of a CPP by this dose of pipradrol. The results suggest that pipradrol produces a rewarding effect and that this effect may involve activation of D1dopamine receptors.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume43
Issue number2
DOIs
StatePublished - Oct 1992
Externally publishedYes

Keywords

  • Affect
  • Conditioned place preference
  • Conditioned reward
  • D
  • Dopamine
  • Motivation
  • Reinforcement
  • Reward
  • SCH23390

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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