Pineal serotonin-N-acetyltransferase activity in four mammalian species

P. Kevin Rudeen, Russel J. Reiter, Mary K. Vaughan

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


The activity of pineal serotonin-N-acetyltransferase (NAT) was compared in four mammalian species: the albino rat, the golden hamster, the Mongolian gerbil and the English short-hair guinea pig. In all species a night-time elevation in pineal NAT activity was apparent. In the rat, pineal NAT activity exhibited a dark:light ratio of 60:1; in the hamster and gerbil the ratio was 3:1 while in the guinea pig the dark:light ratio was 1.5:1. With the exception of the guinea pig, the greatest pineal NAT activity was recorded at 04.00 h (8 h after onset of darkness). In the guinea pig the maximal NAT activity was attained at 24.00 h (4 h after onset of darkness).

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalNeuroscience Letters
Issue number4
StatePublished - Oct 1975

ASJC Scopus subject areas

  • General Neuroscience


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