Pineal removal or denervation: Effects on hypothalamic PRF activity in the rat

David E. Blask, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Medial basal hypothalamic (MBH) extracts from intact, blind-anosmic, blind-anosmic-pinealectomized or nervi conarii transected female rats stimulated the release of prolactin from anterior pituitary glands in vitro. Additionally, a lower tissue level of prolactin was measured in the pituitaries incubated with the extracts. These data indicate that the activity of a prolactin-releasing factor(s) (PRF) was being assayed in the MBH extracts. Additionally, it was observed that MBH extracts from blind-anosmic-pinealectomized or nervi conarii transected rats contained significantly higher levels of PRF activity than the extracts from the intact or blind-anosmic groups. The results support the concept that the pineal control of pituitary prolactin may involve hypothalamic PRF.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume11
Issue number3
DOIs
StatePublished - Sep 1978

Keywords

  • pineal
  • prolactin
  • prolactin-releasing factor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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