Pineal removal or denervation: Effects on hypothalamic PRF activity in the rat

David E. Blask; Russel J. Reiter

doi:10.1016/0303-7207(78)90011-4

Pineal removal or denervation: Effects on hypothalamic PRF activity in the rat

David E. Blask, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Medial basal hypothalamic (MBH) extracts from intact, blind-anosmic, blind-anosmic-pinealectomized or nervi conarii transected female rats stimulated the release of prolactin from anterior pituitary glands in vitro. Additionally, a lower tissue level of prolactin was measured in the pituitaries incubated with the extracts. These data indicate that the activity of a prolactin-releasing factor(s) (PRF) was being assayed in the MBH extracts. Additionally, it was observed that MBH extracts from blind-anosmic-pinealectomized or nervi conarii transected rats contained significantly higher levels of PRF activity than the extracts from the intact or blind-anosmic groups. The results support the concept that the pineal control of pituitary prolactin may involve hypothalamic PRF.

Original language	English (US)
Pages (from-to)	243-248
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0303-7207(78)90011-4
State	Published - Sep 1978

Keywords

pineal
prolactin
prolactin-releasing factor

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Biochemistry

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10.1016/0303-7207(78)90011-4

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abstract = "Medial basal hypothalamic (MBH) extracts from intact, blind-anosmic, blind-anosmic-pinealectomized or nervi conarii transected female rats stimulated the release of prolactin from anterior pituitary glands in vitro. Additionally, a lower tissue level of prolactin was measured in the pituitaries incubated with the extracts. These data indicate that the activity of a prolactin-releasing factor(s) (PRF) was being assayed in the MBH extracts. Additionally, it was observed that MBH extracts from blind-anosmic-pinealectomized or nervi conarii transected rats contained significantly higher levels of PRF activity than the extracts from the intact or blind-anosmic groups. The results support the concept that the pineal control of pituitary prolactin may involve hypothalamic PRF.",

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AU - Blask, David E.

AU - Reiter, Russel J.

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Pineal removal or denervation: Effects on hypothalamic PRF activity in the rat

Abstract

Keywords

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