Pineal parenchymal tumor of intermediate differentiation: A single-institution experience

Joo Yeon Nam, Andrea Gilbert, David Cachia, Jacob Mandel, Gregory N. Fuller, Marta Penas-Prado, John de Groot, Carlos Kamiya-Matsuoka

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background. Pineal parenchymal tumors are exceedingly rare brain tumors responsible for less than 1% of all adult primary intracranial malignancies in the United States. In this study, we describe the clinicopathologic features, management, and outcomes of patients with pineal parenchymal tumor of intermediate differentiation (PPTID). Methods. We describe a single-center, multidisciplinary team experience in managing PPTID patients over a 15-year period (January 2000 to January 2015) at The University of Texas MD Anderson Cancer Center (MDACC). Pathology was reviewed by the pathology collaborators (A.G. and G.N.F.) and retrospective chart review was performed for treatment and clinical outcomes. Results. We identified 17 patients (9 male) with diagnosis of PPTID. Median age at diagnosis of PPTID was 37 years (range, 15-57 years). Follow-up ranged from 0.1 to 162.8 months with 6 reported deaths. Most patients presented with headaches and diplopia. Three patients had neuroaxial dissemination at initial diagnosis, and recurrence of tumor was common (7/16) despite treatment. Conclusions. No clear prognostic factors were identified in this series. Extension of resection showed a trend toward improved survival. PPTID with neuroaxial dissemination benefits from aggressive initial treatment including craniospinal irradiation and adjuvant chemotherapy, whereas localized disease may be treated traditionally with maximum debulking followed by adjuvant radiotherapy alone. Long-term monitoring is recommended for neurotoxicity and/or late recurrence.

Original languageEnglish (US)
Pages (from-to)613-619
Number of pages7
JournalNeuro-Oncology Practice
Issue number6
StatePublished - Dec 1 2020
Externally publishedYes


  • Craniospinal irradiation
  • Parenchymal tumor of intermediate differentiation (PPTID)
  • Pineal parenchymal tumors (PPTs)

ASJC Scopus subject areas

  • Neurology
  • Oncology
  • Medicine (miscellaneous)


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