Pineal opioid receptors and analgesic action of melatonin

Manuchair Ebadi, Piyarat Govitrapong, Pansiri Phansuwan-Pujito, Francine Nelson, Russel J Reiter

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Physicians have noted since antiquity that their patients complained of less pain and required fewer analgesics at night times. In most species, including the humans, the circulating levels of melatonin, a substance with analgesic and hypnotic properties, exhibit a pronounced circadian rhythm with serum levels being high at night and very low during day times. Moreover, melatonin exhibits maximal analgesic effects at night, pinealectomy abolishes the analgesic effects of melatonin, and mu opioid receptor antagonists disrupt the day-night rhythm of nociception. It is believed that melatonin, with its sedative and analgesic effects, is capable of providing a pain free sleep so that the body may recuperate and restore itself to function again at its peak capacity. Moreover, in conditions when pain is associated with extensive tissue injury, melatonin's ability to scavenge free radicals and abort oxidative stress is yet another beneficial effect to be realized. Since melatonin may behave as a mixed opioid receptor agonist-antagonist, it is doubtful that a physician simply could potentiate the analgesic efficacy of narcotics such as morphine by coadministering melatonin. Therefore, future research may synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalJournal of Pineal Research
Volume24
Issue number4
DOIs
StatePublished - 1998

Fingerprint

Opioid Receptors
Melatonin
Opioid Analgesics
Analgesics
Narcotic Antagonists
Narcotics
Hypnotics and Sedatives
Physicians
Pain
Aptitude
Nociception
mu Opioid Receptor
Circadian Rhythm
Analgesia
Morphine
Free Radicals
Sleep
Oxidative Stress
Wounds and Injuries
Serum

Keywords

  • Analgesia
  • Immunoreactive nerve fibers
  • Leu-enkephalin
  • Melatonin
  • Opioid receptor
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology

Cite this

Pineal opioid receptors and analgesic action of melatonin. / Ebadi, Manuchair; Govitrapong, Piyarat; Phansuwan-Pujito, Pansiri; Nelson, Francine; Reiter, Russel J.

In: Journal of Pineal Research, Vol. 24, No. 4, 1998, p. 193-200.

Research output: Contribution to journalArticle

Ebadi, M, Govitrapong, P, Phansuwan-Pujito, P, Nelson, F & Reiter, RJ 1998, 'Pineal opioid receptors and analgesic action of melatonin', Journal of Pineal Research, vol. 24, no. 4, pp. 193-200. https://doi.org/10.1111/j.1600-079X.1998.tb00532.x
Ebadi, Manuchair ; Govitrapong, Piyarat ; Phansuwan-Pujito, Pansiri ; Nelson, Francine ; Reiter, Russel J. / Pineal opioid receptors and analgesic action of melatonin. In: Journal of Pineal Research. 1998 ; Vol. 24, No. 4. pp. 193-200.
@article{d7f9e88044624cd0b7fd5ad1ee944d51,
title = "Pineal opioid receptors and analgesic action of melatonin",
abstract = "Physicians have noted since antiquity that their patients complained of less pain and required fewer analgesics at night times. In most species, including the humans, the circulating levels of melatonin, a substance with analgesic and hypnotic properties, exhibit a pronounced circadian rhythm with serum levels being high at night and very low during day times. Moreover, melatonin exhibits maximal analgesic effects at night, pinealectomy abolishes the analgesic effects of melatonin, and mu opioid receptor antagonists disrupt the day-night rhythm of nociception. It is believed that melatonin, with its sedative and analgesic effects, is capable of providing a pain free sleep so that the body may recuperate and restore itself to function again at its peak capacity. Moreover, in conditions when pain is associated with extensive tissue injury, melatonin's ability to scavenge free radicals and abort oxidative stress is yet another beneficial effect to be realized. Since melatonin may behave as a mixed opioid receptor agonist-antagonist, it is doubtful that a physician simply could potentiate the analgesic efficacy of narcotics such as morphine by coadministering melatonin. Therefore, future research may synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics.",
keywords = "Analgesia, Immunoreactive nerve fibers, Leu-enkephalin, Melatonin, Opioid receptor, Oxidative stress",
author = "Manuchair Ebadi and Piyarat Govitrapong and Pansiri Phansuwan-Pujito and Francine Nelson and Reiter, {Russel J}",
year = "1998",
doi = "10.1111/j.1600-079X.1998.tb00532.x",
language = "English (US)",
volume = "24",
pages = "193--200",
journal = "Journal of Pineal Research",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Pineal opioid receptors and analgesic action of melatonin

AU - Ebadi, Manuchair

AU - Govitrapong, Piyarat

AU - Phansuwan-Pujito, Pansiri

AU - Nelson, Francine

AU - Reiter, Russel J

PY - 1998

Y1 - 1998

N2 - Physicians have noted since antiquity that their patients complained of less pain and required fewer analgesics at night times. In most species, including the humans, the circulating levels of melatonin, a substance with analgesic and hypnotic properties, exhibit a pronounced circadian rhythm with serum levels being high at night and very low during day times. Moreover, melatonin exhibits maximal analgesic effects at night, pinealectomy abolishes the analgesic effects of melatonin, and mu opioid receptor antagonists disrupt the day-night rhythm of nociception. It is believed that melatonin, with its sedative and analgesic effects, is capable of providing a pain free sleep so that the body may recuperate and restore itself to function again at its peak capacity. Moreover, in conditions when pain is associated with extensive tissue injury, melatonin's ability to scavenge free radicals and abort oxidative stress is yet another beneficial effect to be realized. Since melatonin may behave as a mixed opioid receptor agonist-antagonist, it is doubtful that a physician simply could potentiate the analgesic efficacy of narcotics such as morphine by coadministering melatonin. Therefore, future research may synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics.

AB - Physicians have noted since antiquity that their patients complained of less pain and required fewer analgesics at night times. In most species, including the humans, the circulating levels of melatonin, a substance with analgesic and hypnotic properties, exhibit a pronounced circadian rhythm with serum levels being high at night and very low during day times. Moreover, melatonin exhibits maximal analgesic effects at night, pinealectomy abolishes the analgesic effects of melatonin, and mu opioid receptor antagonists disrupt the day-night rhythm of nociception. It is believed that melatonin, with its sedative and analgesic effects, is capable of providing a pain free sleep so that the body may recuperate and restore itself to function again at its peak capacity. Moreover, in conditions when pain is associated with extensive tissue injury, melatonin's ability to scavenge free radicals and abort oxidative stress is yet another beneficial effect to be realized. Since melatonin may behave as a mixed opioid receptor agonist-antagonist, it is doubtful that a physician simply could potentiate the analgesic efficacy of narcotics such as morphine by coadministering melatonin. Therefore, future research may synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics.

KW - Analgesia

KW - Immunoreactive nerve fibers

KW - Leu-enkephalin

KW - Melatonin

KW - Opioid receptor

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=0031976633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031976633&partnerID=8YFLogxK

U2 - 10.1111/j.1600-079X.1998.tb00532.x

DO - 10.1111/j.1600-079X.1998.tb00532.x

M3 - Article

C2 - 9572527

AN - SCOPUS:0031976633

VL - 24

SP - 193

EP - 200

JO - Journal of Pineal Research

JF - Journal of Pineal Research

SN - 0742-3098

IS - 4

ER -