Pineal N-acetyltransferase activity in blinded and anosmic male rats

David C. Klein, Russel J. Reiter, Joan L. Weller

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Abstract

The pineal N-acetyltransferase activity in normal, blinded, anosmic, and anosmicblinded male rats has been examined 10 weeks after surgery at 4 times of the day. In normal animals, the values are about 2700 during the night and 100 during the day. Anosmia does not alter this rhythm. In blinded and blinded-anosmic animals, enzyme activity is not synchronized with time of day. During the 24-hr sampling period, 40% of the blinded and blinded-anosmic animals have enzyme values greater than 2000 units, and 45% have values less than 100 units. Blinded animals are known to have a synchronized diurnal rhythm in N-acetyltransferase 6 days after blinding. Thus it appears quite possible that, 10 weeks after surgery, the rhythm in blinded individual animals has become asynchronous relative to the rhythm in other blinded animals.

Original languageEnglish (US)
Pages (from-to)1020-1023
Number of pages4
JournalEndocrinology
Volume89
Issue number4
DOIs
Publication statusPublished - Oct 1971

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ASJC Scopus subject areas

  • Endocrinology

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