Pineal methoxyindoles: new evidence concerning their function in the control of pinal mediated changes in the reproductive physiology of male golden hamsters

Russel J Reiter, M. K. Vaughan, D. E. Blask, Linda Y Johnson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Maintaining adult male golden hamsters in short daily photoperiods (1 hr of light and 23 hr of darkness daily; LD 1:23) for 12 wk caused the testes and accessory sex organs to atrophy and also led to significant depressions in pituitary LH and prolactin levels. If hamsters that were kept in LD 1:23 cycles received weekly subcutaneous implants of either a melatonin beeswax or a 5 methoxytryptophol beeswax pellet (1 mg indole in 24 mg beeswax) the testes and accessory sex organs failed to involute and pituitary LH levels did not drop. Both treatments also retarded the depression in hypophyseal prolactin levels. Treatment (twice daily on weekdays and once daily on weekends) with 1.5 μg injections of synthetic LRH (in 0.2 ml 8% gelatin) did not prevent gonadal or accessory organ atrophy while it further depressed hypophyseal LH stores. Following LRH treatment, plasma LH titers were significantly elevated. The reproductive organs of hamsters that were moved from short (LD 1:23) to long (LD 14:10) daily photoperiods regenerated within 8 wk. The light induced restoration of the gonads was not prevented or retarded by the weekly implantation of either melatonin beeswax or 5 methoxytryptophol beeswax pellets. The results suggest that in the male golden hamster neither melatonin nor 5 methoxytryptophol accounts for the antigonadotrophic activity of the pineal gland.

Original languageEnglish (US)
Pages (from-to)206-213
Number of pages8
JournalEndocrinology
Volume96
Issue number1
StatePublished - 1975

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Mesocricetus
Melatonin
Genitalia
Photoperiod
Cricetinae
Prolactin
Atrophy
Testis
Light
Pineal Gland
Darkness
Gonads
Gelatin
Therapeutics
beeswax
pinal
Injections
methoxytryptophol

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Pineal methoxyindoles: new evidence concerning their function in the control of pinal mediated changes in the reproductive physiology of male golden hamsters",
abstract = "Maintaining adult male golden hamsters in short daily photoperiods (1 hr of light and 23 hr of darkness daily; LD 1:23) for 12 wk caused the testes and accessory sex organs to atrophy and also led to significant depressions in pituitary LH and prolactin levels. If hamsters that were kept in LD 1:23 cycles received weekly subcutaneous implants of either a melatonin beeswax or a 5 methoxytryptophol beeswax pellet (1 mg indole in 24 mg beeswax) the testes and accessory sex organs failed to involute and pituitary LH levels did not drop. Both treatments also retarded the depression in hypophyseal prolactin levels. Treatment (twice daily on weekdays and once daily on weekends) with 1.5 μg injections of synthetic LRH (in 0.2 ml 8{\%} gelatin) did not prevent gonadal or accessory organ atrophy while it further depressed hypophyseal LH stores. Following LRH treatment, plasma LH titers were significantly elevated. The reproductive organs of hamsters that were moved from short (LD 1:23) to long (LD 14:10) daily photoperiods regenerated within 8 wk. The light induced restoration of the gonads was not prevented or retarded by the weekly implantation of either melatonin beeswax or 5 methoxytryptophol beeswax pellets. The results suggest that in the male golden hamster neither melatonin nor 5 methoxytryptophol accounts for the antigonadotrophic activity of the pineal gland.",
author = "Reiter, {Russel J} and Vaughan, {M. K.} and Blask, {D. E.} and Johnson, {Linda Y}",
year = "1975",
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PY - 1975

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AB - Maintaining adult male golden hamsters in short daily photoperiods (1 hr of light and 23 hr of darkness daily; LD 1:23) for 12 wk caused the testes and accessory sex organs to atrophy and also led to significant depressions in pituitary LH and prolactin levels. If hamsters that were kept in LD 1:23 cycles received weekly subcutaneous implants of either a melatonin beeswax or a 5 methoxytryptophol beeswax pellet (1 mg indole in 24 mg beeswax) the testes and accessory sex organs failed to involute and pituitary LH levels did not drop. Both treatments also retarded the depression in hypophyseal prolactin levels. Treatment (twice daily on weekdays and once daily on weekends) with 1.5 μg injections of synthetic LRH (in 0.2 ml 8% gelatin) did not prevent gonadal or accessory organ atrophy while it further depressed hypophyseal LH stores. Following LRH treatment, plasma LH titers were significantly elevated. The reproductive organs of hamsters that were moved from short (LD 1:23) to long (LD 14:10) daily photoperiods regenerated within 8 wk. The light induced restoration of the gonads was not prevented or retarded by the weekly implantation of either melatonin beeswax or 5 methoxytryptophol beeswax pellets. The results suggest that in the male golden hamster neither melatonin nor 5 methoxytryptophol accounts for the antigonadotrophic activity of the pineal gland.

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