Pineal melatonin rhythm: Reduction in aging syrian hamsters

Russel J. Reiter; Bruce A. Richardson; Linda Y. Johnson; Bonnie N. Ferguson; Diep T. Dinh

doi:10.1126/science.7434032

Pineal melatonin rhythm: Reduction in aging syrian hamsters

Russel J. Reiter, Bruce A. Richardson, Linda Y. Johnson, Bonnie N. Ferguson, Diep T. Dinh

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

The melatonin content measured by radioimmunoassay of the pineal gland over a 24-hour period (a light: dark cycle of 14 hours of light and 10 of darkness) was compared in young and old female and male Syrian hamsters. The young animals of both sexes exhibited roughly an eightfold rise in pineal melatonin during the dark phase of the cycle, whereas in the old hamsters the nocturnal rise in melatonin was almost completely absent. The results indicate a marked drop in pineal biosynthetic activity in the aging hamster.

Original language	English (US)
Pages (from-to)	1372-1373
Number of pages	2
Journal	Science
Volume	210
Issue number	4476
DOIs	https://doi.org/10.1126/science.7434032
State	Published - Jan 1 1980

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title = "Pineal melatonin rhythm: Reduction in aging syrian hamsters",

abstract = "The melatonin content measured by radioimmunoassay of the pineal gland over a 24-hour period (a light: dark cycle of 14 hours of light and 10 of darkness) was compared in young and old female and male Syrian hamsters. The young animals of both sexes exhibited roughly an eightfold rise in pineal melatonin during the dark phase of the cycle, whereas in the old hamsters the nocturnal rise in melatonin was almost completely absent. The results indicate a marked drop in pineal biosynthetic activity in the aging hamster.",

author = "Reiter, {Russel J.} and Richardson, {Bruce A.} and Johnson, {Linda Y.} and Ferguson, {Bonnie N.} and Dinh, {Diep T.}",

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T2 - Reduction in aging syrian hamsters

AU - Reiter, Russel J.

AU - Richardson, Bruce A.

AU - Johnson, Linda Y.

AU - Ferguson, Bonnie N.

AU - Dinh, Diep T.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - The melatonin content measured by radioimmunoassay of the pineal gland over a 24-hour period (a light: dark cycle of 14 hours of light and 10 of darkness) was compared in young and old female and male Syrian hamsters. The young animals of both sexes exhibited roughly an eightfold rise in pineal melatonin during the dark phase of the cycle, whereas in the old hamsters the nocturnal rise in melatonin was almost completely absent. The results indicate a marked drop in pineal biosynthetic activity in the aging hamster.

AB - The melatonin content measured by radioimmunoassay of the pineal gland over a 24-hour period (a light: dark cycle of 14 hours of light and 10 of darkness) was compared in young and old female and male Syrian hamsters. The young animals of both sexes exhibited roughly an eightfold rise in pineal melatonin during the dark phase of the cycle, whereas in the old hamsters the nocturnal rise in melatonin was almost completely absent. The results indicate a marked drop in pineal biosynthetic activity in the aging hamster.

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Pineal melatonin rhythm: Reduction in aging syrian hamsters

Abstract

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